tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2021 Nov 2;28(1).
doi: 10.3201/eid2801.211749. Online ahead of print.
Postmortem Antigen-Detecting Rapid Diagnostic Tests to Predict Infectivity of SARS-CoV-2-Associated Deaths
Fabian Heinrich, Ann Sophie Schröder, Anna-Lina Gerberding, Moritz Gerling, Felicia Langenwalder, Philine Lange, Axel Heinemann, Eric Bibiza-Freiwald, Dominik Sebastian Nörz, Martin Aepfelbacher, Susanne Pfefferle, Benjamin Ondruschka, Marc Lütgehetmann
Abstract
We investigated the infectivity of 128 severe acute respiratory disease coronavirus 2-associated deaths and evaluated predictive values of standard diagnostic procedures. Maintained infectivity (20%) did not correlate with viral RNA loads but correlated well with anti-S antibody levels. Sensitivity >90% for antigen-detecting rapid diagnostic tests supports their usefulness for assessment.
Keywords: Ag-RDT; COVID-19; SARS-CoV-2; antigen-detecting rapid diagnostic test; coronavirus; coronavirus disease 2019; infectivity; postmortem; respiratory infections; serostatus; severe acute respiratory syndrome coronavirus 2; viral RNA load; viruses; zoonoses.
. 2021 Nov 2;28(1).
doi: 10.3201/eid2801.211749. Online ahead of print.
Postmortem Antigen-Detecting Rapid Diagnostic Tests to Predict Infectivity of SARS-CoV-2-Associated Deaths
Fabian Heinrich, Ann Sophie Schröder, Anna-Lina Gerberding, Moritz Gerling, Felicia Langenwalder, Philine Lange, Axel Heinemann, Eric Bibiza-Freiwald, Dominik Sebastian Nörz, Martin Aepfelbacher, Susanne Pfefferle, Benjamin Ondruschka, Marc Lütgehetmann
- PMID: 34726595
- DOI: 10.3201/eid2801.211749
Abstract
We investigated the infectivity of 128 severe acute respiratory disease coronavirus 2-associated deaths and evaluated predictive values of standard diagnostic procedures. Maintained infectivity (20%) did not correlate with viral RNA loads but correlated well with anti-S antibody levels. Sensitivity >90% for antigen-detecting rapid diagnostic tests supports their usefulness for assessment.
Keywords: Ag-RDT; COVID-19; SARS-CoV-2; antigen-detecting rapid diagnostic test; coronavirus; coronavirus disease 2019; infectivity; postmortem; respiratory infections; serostatus; severe acute respiratory syndrome coronavirus 2; viral RNA load; viruses; zoonoses.