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Emerg Infect Dis. Oseltamivir- and Amantadine-Resistant Influenza Viruses A (H1N1)

Giuseppe

Giuseppe

Emeritus
Oseltamivir- and Amantadine-Resistant Influenza Viruses A (H1N1) (EID, abstract, edited)

[Original Full Document: LINK. EDITED.]

DOI: 10.3201/eid1506.081357
Suggested citation for this article: Cheng PKC, Leung TWC, Ho ECM, Leung PCK, Ng AYY, Lai MYY, et al. Oseltamivir- and amantadine-resistant influenza viruses A (H1N1). Emerg Infect Dis. 2009 Jun; [Epub ahead of print]

Oseltamivir- and Amantadine-Resistant Influenza Viruses A (H1N1)

Peter K.C. Cheng, Tommy W.C. Leung, Eric C.M. Ho, Peter C.K. Leung, Anita Y.Y. Ng, Mary Y.Y. Lai, and Wilina W.L. Lim

Author affiliation: Centre for Health Protection, Hong Kong Special Administrative Region, People?s Republic of China


Surveillance of amantadine and oseltamivir resistance among influenza viruses was begun in Hong Kong in 2006. In 2008, while both A/Brisbane/59/2007-like and A/Hong Kong/2652/2006-like viruses (H1N1) were cocirculating, we detected amantadine- and oseltamivir-resistance among A/Hong Kong/2652/2006-like viruses (H1N1), caused by genetic reassortment or spontaneous mutation.

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Attachments

Re: Emerg Infect Dis. Oseltamivir- and Amantadine-Resistant Influenza Viruses A (H1N1)

<a rel="nofollow" href="http://www.recombinomics.com/News/10020801/H274Y_2BX2C.html">Commentary</a>

Genetic Exchanges Between H1N1 Clade 2B and 2C

Recombinomics Commentary 12:01
October 2, 2008

Three sets of partial HA and NA sequences from Hong Kong are being released at Genbank. All three HA sequences are Hong Kong/2562 (clade 2C) and phylogenetically map to two 2C sub-clades. All three NA sequences have H274Y, but only two of the NA sequences are clade 2C. The third sequence, A/HongKong/942/2008, exactly matches an earlier sequence from Hong Kong, A/Hong Kong/17/2008, as well as other clade 2B sequences from South Africa, France, England, and the United States (see list here). Thus, this isolate is a reassortant, with a clade 2C HA sequence and a clade 2B NA sequence...............

 
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