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Emerg Infect Dis . New SARS-CoV-2 Omicron Variant with Spike Protein Mutation Y451H, Kilifi, Kenya, March-May 2023

tetano

tetano

Editor, Senior Moderator
Emerg Infect Dis


. 2023 Sep 14;29(11).
doi: 10.3201/eid2911.230894. Online ahead of print.
New SARS-CoV-2 Omicron Variant with Spike Protein Mutation Y451H, Kilifi, Kenya, March-May 2023

Mike J Mwanga, Arnold W Lambisia, John Mwita Morobe, Nickson Murunga, Edidah Moraa, Leonard Ndwiga, Robinson Cheruiyot, Jennifer Musyoki, Martin Mutunga, Laura M Guzman-Rincon, Charles Sande, Joseph Mwangangi, Philip Bejon, Lynette Isabella Ochola-Oyier, D James Nokes, Charles N Agoti, Joyce Nyiro, George Githinji
Abstract

We report a newly emerged SARS-CoV-2 Omicron subvariant FY.4 that has mutations Y451H in spike and P42L in open reading frame 3a proteins. FY.4 emergence coincided with increased SARS-CoV-2 cases in coastal Kenya during April-May 2023. Continued SARS-CoV-2 genomic surveillance is needed to identify new lineages to inform COVID-19 outbreak prevention.

Keywords: COVID-19; FY.4; Kenya; Kilifi; Omicron; SARS; SARS-CoV-2; coronavirus; coronavirus disease; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.
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