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Emerg Infect Dis. Neurologic Manifestations of Pandemic (H1N1) 2009 Virus Infection

Giuseppe

Emeritus
Neurologic Manifestations of Pandemic (H1N1) 2009 Virus Infection (Emerg Infect Dis., extract, edited)

[Source Full PDF Document: LINK. EDITED.]

DOI: 10.3201/eid1603.091699
Suggested citation for this article: Kitcharoen S, Pattapongsin M, Sawanyawisuth K, Angela V, Tiamkao S. Neurologic manifestations of pandemic (H1N1) 2009 virus infection [letter]. Emerg Infect Dis. 2010 Mar; [Epub ahead of print]

Neurologic Manifestations of Pandemic (H1N1) 2009 Virus Infection


To the Editor:

In April 2009, the outbreak of influenza A pandemic (H1N1) 2009 virus was reported. Subsequently, the disease spread throughout the world, and the pandemic alert level was raised to level 6 in June by the World Health Organization. Pandemic (H1N1) 2009 virus infection spread to Thailand and is now found throughout Thailand. Similar to the effects of other viruses, pandemic (H1N1) 2009 virus may cause neurologic complications. Associated neurologic symptoms were first reported from Dallas, Texas, USA: 4 children experienced unexplained seizures or had an alteration of consciousness level that was associated with this virus (1). We report an adult patient with pandemic (H1N1) 2009 infection who had neurologic complications.

A 34-year-old man, previously healthy, was admitted to Chaiyaphum Hospital in Chaiyaphum, Thailand, on August 24, 2009, with influenza-like symptoms. Two days after admission, progressive quadriparesis with bilateral, symmetric paresthesia (glove-and-stocking pattern), and areflexia developed. His motor weakness (grades III/V) began in both legs and then involved both arms and hands. Other neurologic examinations showed limitation of extraocular movement in all directions, normal pupil size and light reflex, and facial diplegia. A lumbar puncture was performed, and cerebrospinal fluid (CSF) contained neither white or red blood cells with a protein level of 19.5 mg/dL.
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Re: Emerg Infect Dis. Neurologic Manifestations of Pandemic (H1N1) 2009 Virus Infection

How does this compare to the CNS symptoms seen in some H5N1 patients?

Also, remember the leg paralysis in some animals with H5N1? Same thing?

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