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Emerg Infect Dis . Isolation of Infectious Highly Pathogenic Avian Influenza A(H5N1) Virus from Fetal Bovine Serum, United States, 2025

tetano

Editor, Senior Moderator
Emerg Infect Dis


. 2026 Jul 9;32(8).
doi: 10.3201/eid3208.260077. Online ahead of print.
Isolation of Infectious Highly Pathogenic Avian Influenza A(H5N1) Virus from Fetal Bovine Serum, United States, 2025

Ana R Rebelo, Erica Buttler, Elizabeth Aguilera Nunez, Brittany Cronk, Jennifer Powers, Melissa Laverack, Chen Feng, Mohammed Nooruzzaman, Mia K Torchetti, Leonardo C Caserta, Diego G Diel
Free article Abstract

In February 2025, we detected highly pathogenic avian influenza virus A(H5N1) clade 2.3.4.4b virus in a fetal bovine serum lot during routine adventitious agent testing. Sequencing confirmed H5N1 genotype B3.13 virus. We found low viral loads in additional samples from the same lot. Heating at 56°C for 30 minutes completely inactivated the virus.

Keywords: H5N1; United States; highly pathogenic avian influenza; influenza; viruses; zoonoses.

 
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