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Emerg Infect Dis . Investigation of Influenza A(H5N1) Virus Neutralization by Quadrivalent Seasonal Vaccines, United Kingdom, 2021-2024

tetano

tetano

Editor, Senior Moderator
Emerg Infect Dis


. 2025 Jun;31(6):1202-1206.
doi: 10.3201/eid3106.241796. Investigation of Influenza A(H5N1) Virus Neutralization by Quadrivalent Seasonal Vaccines, United Kingdom, 2021-2024

Phoebe Stevenson-Leggett, Lorin Adams, David Greenwood, Abi Lofts, Vincenzo Libri, Bryan Williams, Sonia Gandhi, Charles Swanton, Steve Gamblin, Edward J Carr, Ruth Harvey, Nicola S Lewis, Mary Y Wu, Emma C Wall; Crick Neutralization Consortium; Legacy Investigators; Crick Neutralization Consortium and Legacy Investigators



Collaborators
Free article Abstract

We tested cross-neutralization against highly pathogenic avian influenza A(H5N1) virus in adults vaccinated with 2021-2023 seasonal quadrivalent influenza vaccine in the United Kingdom. Seasonal quadrivalent influenza vaccines are unlikely to protect vulnerable persons against severe H5N1 disease during widespread transmission. Enhanced measures are needed to protect vulnerable people from H5N1 virus infection.

Keywords: United Kingdom; highly pathogenic avian influenza; influenza; influenza A; neutralization; quadrivalent influenza vaccine; viruses; zoonoses; zoonotic transmission.

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