tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2021 May;27(5):1492-1495.
doi: 10.3201/eid2705.210015.
Introduction of ORF3a-Q57H SARS-CoV-2 Variant Causing Fourth Epidemic Wave of COVID-19, Hong Kong, China
Daniel K W Chu, Kenrie P Y Hui, Haogao Gu, Ronald L W Ko, Pavithra Krishnan, Daisy Y M Ng, Gigi Y Z Liu, Carrie K C Wan, Man-Chun Cheung, Ka-Chun Ng, John M Nicholls, Dominic N C Tsang, Malik Peiris, Michael C W Chan, Leo L M Poon
Abstract
We describe an introduction of clade GH severe acute respiratory syndrome coronavirus 2 causing a fourth wave of coronavirus disease in Hong Kong. The virus has an ORF3a-Q57H mutation, causing truncation of ORF3b. This virus evades induction of cytokine, chemokine, and interferon-stimulated gene expression in primary human respiratory cells.
Keywords: COVID-19; China; Hong Kong; SARS; SARS-CoV-2; coronavirus; coronavirus disease; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.
. 2021 May;27(5):1492-1495.
doi: 10.3201/eid2705.210015.
Introduction of ORF3a-Q57H SARS-CoV-2 Variant Causing Fourth Epidemic Wave of COVID-19, Hong Kong, China
Daniel K W Chu, Kenrie P Y Hui, Haogao Gu, Ronald L W Ko, Pavithra Krishnan, Daisy Y M Ng, Gigi Y Z Liu, Carrie K C Wan, Man-Chun Cheung, Ka-Chun Ng, John M Nicholls, Dominic N C Tsang, Malik Peiris, Michael C W Chan, Leo L M Poon
- PMID: 33900193
- DOI: 10.3201/eid2705.210015
Abstract
We describe an introduction of clade GH severe acute respiratory syndrome coronavirus 2 causing a fourth wave of coronavirus disease in Hong Kong. The virus has an ORF3a-Q57H mutation, causing truncation of ORF3b. This virus evades induction of cytokine, chemokine, and interferon-stimulated gene expression in primary human respiratory cells.
Keywords: COVID-19; China; Hong Kong; SARS; SARS-CoV-2; coronavirus; coronavirus disease; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.