tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2025 Apr 3;31(5).
doi: 10.3201/eid3105.241123. Online ahead of print.
Influenza A(H1N1)pdm09 Virus with Reduced Susceptibility to Baloxavir, Japan, 2024
Emi Takashita, Hiroko Morita, Shiho Nagata, Seiichiro Fujisaki, Hideka Miura, Tatsuya Ikeda, Kenichi Komabayashi, Mika Sasaki, Yohei Matoba, Tomoko Takahashi, Naomi Ogawa, Katsumi Mizuta, Sueshi Ito, Noriko Kishida, Kazuya Nakamura, Masayuki Shirakura, Shinji Watanabe, Hideki Hasegawa
Influenza A(H1N1)pdm09 virus carrying an I38N substitution was detected in an untreated teenager in Japan. The I38N mutant virus exhibited reduced susceptibility to baloxavir but remained susceptible to neuraminidase inhibitors and showed reduced growth capability. Monitoring antiviral drug susceptibility of influenza viruses is necessary to aid public health planning and clinical recommendations.
Keywords: A(H1N1)pdm09; I38N substitution; Japan; antimicrobial resistance; baloxavir acid; baloxavir marboxil; cap-dependent endonuclease inhibitor; drug resistance; influenza; influenza virus; polymerase acidic protein; respiratory infections; viruses.
. 2025 Apr 3;31(5).
doi: 10.3201/eid3105.241123. Online ahead of print.
Influenza A(H1N1)pdm09 Virus with Reduced Susceptibility to Baloxavir, Japan, 2024
Emi Takashita, Hiroko Morita, Shiho Nagata, Seiichiro Fujisaki, Hideka Miura, Tatsuya Ikeda, Kenichi Komabayashi, Mika Sasaki, Yohei Matoba, Tomoko Takahashi, Naomi Ogawa, Katsumi Mizuta, Sueshi Ito, Noriko Kishida, Kazuya Nakamura, Masayuki Shirakura, Shinji Watanabe, Hideki Hasegawa
- PMID: 40180581
- DOI: 10.3201/eid3105.241123
Influenza A(H1N1)pdm09 virus carrying an I38N substitution was detected in an untreated teenager in Japan. The I38N mutant virus exhibited reduced susceptibility to baloxavir but remained susceptible to neuraminidase inhibitors and showed reduced growth capability. Monitoring antiviral drug susceptibility of influenza viruses is necessary to aid public health planning and clinical recommendations.
Keywords: A(H1N1)pdm09; I38N substitution; Japan; antimicrobial resistance; baloxavir acid; baloxavir marboxil; cap-dependent endonuclease inhibitor; drug resistance; influenza; influenza virus; polymerase acidic protein; respiratory infections; viruses.