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Emerg Infect Dis. Inadequate Antibody Response to Rabies Vaccine in Immunocompromised Patient

Giuseppe

Emeritus
[Source: US Centers for Diseases Control and Prevention, Emerging Infectious Diseases Journal, full page: (LINK). Abstract, edited.]

Volume 18, Number 9?September 2012

Dispatch

Inadequate Antibody Response to Rabies Vaccine in Immunocompromised Patient


Eran Kopel, Gal Oren, Yechezkel Sidi, and Dan David

Author affiliations: The Chaim Sheba Medical Center, Tel Hashomer, Israel (E. Kopel, G. Oren, Y. Sidi); Ministry of Health, Tel Aviv, Israel (E. Kopel); Sackler School of Medicine, Tel Aviv University, Tel Aviv (Y. Sidi); and Kimron Veterinary Institute, Bet Dagan, Israel (D. David)



Abstract


We describe an inadequate antibody response to rabies vaccine in an immunocompromised patient. A literature search revealed 15 additional immunocompromised patients, of whom 7 did not exhibit the minimum acceptable level of antibodies after a complete postexposure prophylaxis regimen. An international rabies registry is needed to provide a basis for determining appropriate vaccination protocols.
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