tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2022 Aug 4;28(9).
doi: 10.3201/eid2809.220875. Online ahead of print.
Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person
Bas B Oude Munnink, Roel H T Nijhuis, Nathalie Worp, Marjan Boter, Babette Weller, Babs E Verstrepen, Corine GeurtsvanKessel, Maarten L Corsten, Anne Russcher, Marion Koopmans
Abstract
We detected a highly divergent SARS-CoV-2 Alpha variant in an immunocompromised person several months after the latest detection of the Alpha variant in the Netherlands. The patient was infected for 42 weeks despite several treatment regimens and disappearance of most clinical symptoms. We identified several potential immune escape mutations in the spike protein.
Keywords: Alpha variant; COVID-19; SARS-CoV-2; coronavirus disease; immunocompromised; respiratory infections; severe acute respiratory syndrome coronavirus 2; the Netherlands; variants; virus evolution; viruses; zoonoses.
. 2022 Aug 4;28(9).
doi: 10.3201/eid2809.220875. Online ahead of print.
Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person
Bas B Oude Munnink, Roel H T Nijhuis, Nathalie Worp, Marjan Boter, Babette Weller, Babs E Verstrepen, Corine GeurtsvanKessel, Maarten L Corsten, Anne Russcher, Marion Koopmans
- PMID: 35925013
- DOI: 10.3201/eid2809.220875
Abstract
We detected a highly divergent SARS-CoV-2 Alpha variant in an immunocompromised person several months after the latest detection of the Alpha variant in the Netherlands. The patient was infected for 42 weeks despite several treatment regimens and disappearance of most clinical symptoms. We identified several potential immune escape mutations in the spike protein.
Keywords: Alpha variant; COVID-19; SARS-CoV-2; coronavirus disease; immunocompromised; respiratory infections; severe acute respiratory syndrome coronavirus 2; the Netherlands; variants; virus evolution; viruses; zoonoses.