Giuseppe
Emeritus
[Source: US Centers for Disease Control and Prevention, Emerging Infectious Diseases Journal, full text: (LINK). Abstract, edited.]
Volume 17, Number 5?May 2011
Research
Volume 17, Number 5?May 2011
Research
Genotypic Profile of Streptococcus suis Serotype 2 and Clinical Features of Infection in Humans, Thailand
Anusak Kerdsin, Surang Dejsirilert, Parichart Puangpatra, Saowalak Sripakdee, Koranan Chumla, Nitsara Boonkerd, Pitimol Polwichai, Susumu Tanimura, Dan Takeuchi, Tatsuya Nakayama, Shota Nakamura, Yukihiro Akeda, Marcelo Gottschalk, Pathom Sawanpanyalert, and Kazunori Oishi
Author affiliations: Ministry of Public Health, Nonthaburi, Thailand (A. Kerdsin, S. Dejsirilert, P. Puangpatra, S. Sripakdee, K. Chumla, N. Boonkerd, P. Polwichai, P. Sawanpanyalert); Naresuan University Phayao Campus, Phayao, Thailand (N. Boonkerd); Hyogo College of Medicine, Nishinomiya, Japan (S. Tanimura); Osaka University, Osaka, Japan (D. Takeuchi, T. Nakayama, Y. Akeda, K. Oishi); Thailand-Japan Research Collaboration Center for Emerging and Re-emerging Infections, Nonthaburi (S. Nakamura); and University of Montreal, Quebec, Canada (M. Gottschalk)
Suggested citation for this article
Abstract
To examine associations between clinical features of Streptococcus suis serotype 2 infections in humans in Thailand and genotypic profiles of isolates, we conducted a retrospective study during 2006?2008. Of 165 patients for whom bacterial cultures of blood, cerebrospinal fluid, or both were positive for S. suis serotype 2, the major multilocus sequence types (STs) found were ST1 (62.4%) and ST104 (25.5%); the latter is unique to Thailand. Clinical features were examined for 158 patients. Infections were sporadic; case-fatality rate for adults was 9.5%, primarily in northern Thailand. Disease incidence peaked during the rainy season. Disease was classified as meningitis (58.9%) or nonmeningitis (41.1%, and included sepsis [35.4%] and others [5.7%]). Although ST1 strains were significantly associated with the meningitis category (p<0.0001), ST104 strains were significantly associated with the nonmeningitis category (p<0.0001). The ST1 and ST104 strains are capable of causing sepsis, but only the ST1 strains commonly cause meningitis.
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Anusak Kerdsin, Surang Dejsirilert, Parichart Puangpatra, Saowalak Sripakdee, Koranan Chumla, Nitsara Boonkerd, Pitimol Polwichai, Susumu Tanimura, Dan Takeuchi, Tatsuya Nakayama, Shota Nakamura, Yukihiro Akeda, Marcelo Gottschalk, Pathom Sawanpanyalert, and Kazunori Oishi
Author affiliations: Ministry of Public Health, Nonthaburi, Thailand (A. Kerdsin, S. Dejsirilert, P. Puangpatra, S. Sripakdee, K. Chumla, N. Boonkerd, P. Polwichai, P. Sawanpanyalert); Naresuan University Phayao Campus, Phayao, Thailand (N. Boonkerd); Hyogo College of Medicine, Nishinomiya, Japan (S. Tanimura); Osaka University, Osaka, Japan (D. Takeuchi, T. Nakayama, Y. Akeda, K. Oishi); Thailand-Japan Research Collaboration Center for Emerging and Re-emerging Infections, Nonthaburi (S. Nakamura); and University of Montreal, Quebec, Canada (M. Gottschalk)
Suggested citation for this article
Abstract
To examine associations between clinical features of Streptococcus suis serotype 2 infections in humans in Thailand and genotypic profiles of isolates, we conducted a retrospective study during 2006?2008. Of 165 patients for whom bacterial cultures of blood, cerebrospinal fluid, or both were positive for S. suis serotype 2, the major multilocus sequence types (STs) found were ST1 (62.4%) and ST104 (25.5%); the latter is unique to Thailand. Clinical features were examined for 158 patients. Infections were sporadic; case-fatality rate for adults was 9.5%, primarily in northern Thailand. Disease incidence peaked during the rainy season. Disease was classified as meningitis (58.9%) or nonmeningitis (41.1%, and included sepsis [35.4%] and others [5.7%]). Although ST1 strains were significantly associated with the meningitis category (p<0.0001), ST104 strains were significantly associated with the nonmeningitis category (p<0.0001). The ST1 and ST104 strains are capable of causing sepsis, but only the ST1 strains commonly cause meningitis.
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