tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2021 Apr 2;27(5).
doi: 10.3201/eid2705.204912. Online ahead of print.
Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil
Natalia Fintelman-Rodrigues, Aline P D da Silva, Monique Cristina Dos Santos, Felipe B Saraiva, Marcelo A Ferreira, Jo?o Gesto, Danielle A S Rodrigues, Andr? M Vale, Isaclaudia G de Azevedo, Vin?cius C Soares, Hui Jiang, Hongdong Tan, Diogo A Tschoeke, Carolina Q Sacramento, Fernando A Bozza, Carlos M Morel, Patr?cia T Bozza, Thiago Moreno L Souza
Abstract
The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. The second episode was associated with different SARS-CoV-2 strains, higher viral loads, and clinical symptoms. Our finding that persons with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity suggests that reinfection is more frequent than supposed, but this hypothesis is not well documented.
Keywords: Brazil; COVID-19; SARS-CoV-2; coronavirus disease; humoral response; next-generation sequencing; reinfection; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.
. 2021 Apr 2;27(5).
doi: 10.3201/eid2705.204912. Online ahead of print.
Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil
Natalia Fintelman-Rodrigues, Aline P D da Silva, Monique Cristina Dos Santos, Felipe B Saraiva, Marcelo A Ferreira, Jo?o Gesto, Danielle A S Rodrigues, Andr? M Vale, Isaclaudia G de Azevedo, Vin?cius C Soares, Hui Jiang, Hongdong Tan, Diogo A Tschoeke, Carolina Q Sacramento, Fernando A Bozza, Carlos M Morel, Patr?cia T Bozza, Thiago Moreno L Souza
- PMID: 33797393
- DOI: 10.3201/eid2705.204912
Abstract
The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. The second episode was associated with different SARS-CoV-2 strains, higher viral loads, and clinical symptoms. Our finding that persons with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity suggests that reinfection is more frequent than supposed, but this hypothesis is not well documented.
Keywords: Brazil; COVID-19; SARS-CoV-2; coronavirus disease; humoral response; next-generation sequencing; reinfection; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.