Giuseppe
Emeritus
[Source: Centers for Disease Control and Prevention, USA, Emerging Infectious Diseases Journal, full text: (LINK). Abstract, edited.]
Volume 18, Number 8?August 2012
CME ACTIVITY
CME ACTIVITY
Factors Related to Increasing Prevalence of Resistance to Ciprofloxacin and Other Antimicrobial Drugs in Neisseria gonorrhoeae, United States
Edward Goldstein, Robert D. Kirkcaldy, David Reshef, Stuart Berman, Hillard Weinstock, Pardis Sabeti, Carlos Del Rio, Geraldine Hall, Edward W. Hook, and Marc Lipsitch
Author affiliations: Harvard School of Public Health, Boston, Massachusetts, USA (E. Goldstein, M. Lipsitch); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (R.D. Kirkcaldy, S. Berman, H. Weinstock); Oxford University, Oxford, UK (D. Reshef); Harvard University, Cambridge, Massachusetts, USA (P. Sabeti); Emory University, Atlanta (C. Del Rio); Cleveland Clinic, Cleveland, Ohio, USA (G. Hall); University of Alabama at Birmingham, Birmingham, Alabama, USA (E.W. Hook); and Jefferson County Department of Health, Birmingham (E.W. Hook)
Abstract
Using data from the Gonococcal Isolate Surveillance Project, we studied changes in ciprofloxacin resistance in Neisseria gonorrhoeae isolates in the United States during 2002?2007. Compared with prevalence in heterosexual men, prevalence of ciprofloxacin-resistant N. gonorrhoeae infections showed a more pronounced increase in men who have sex with men (MSM), particularly through an increase in prevalence of strains also resistant to tetracycline and penicillin. Moreover, that multidrug resistance profile among MSM was negatively associated with recent travel. Across the surveillance project sites, first appearance of ciprofloxacin resistance in heterosexual men was positively correlated with such resistance for MSM. The increase in prevalence of ciprofloxacin resistance may have been facilitated by use of fluoroquinolones for treating gonorrhea and other conditions. The prominence of multidrug resistance suggests that using other classes of antimicrobial drugs for purposes other than treating gonorrhea helped increase the prevalence of ciprofloxacin-resistant strains that are also resistant to those drugs.
- ------Edward Goldstein, Robert D. Kirkcaldy, David Reshef, Stuart Berman, Hillard Weinstock, Pardis Sabeti, Carlos Del Rio, Geraldine Hall, Edward W. Hook, and Marc Lipsitch
Author affiliations: Harvard School of Public Health, Boston, Massachusetts, USA (E. Goldstein, M. Lipsitch); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (R.D. Kirkcaldy, S. Berman, H. Weinstock); Oxford University, Oxford, UK (D. Reshef); Harvard University, Cambridge, Massachusetts, USA (P. Sabeti); Emory University, Atlanta (C. Del Rio); Cleveland Clinic, Cleveland, Ohio, USA (G. Hall); University of Alabama at Birmingham, Birmingham, Alabama, USA (E.W. Hook); and Jefferson County Department of Health, Birmingham (E.W. Hook)
Abstract
Using data from the Gonococcal Isolate Surveillance Project, we studied changes in ciprofloxacin resistance in Neisseria gonorrhoeae isolates in the United States during 2002?2007. Compared with prevalence in heterosexual men, prevalence of ciprofloxacin-resistant N. gonorrhoeae infections showed a more pronounced increase in men who have sex with men (MSM), particularly through an increase in prevalence of strains also resistant to tetracycline and penicillin. Moreover, that multidrug resistance profile among MSM was negatively associated with recent travel. Across the surveillance project sites, first appearance of ciprofloxacin resistance in heterosexual men was positively correlated with such resistance for MSM. The increase in prevalence of ciprofloxacin resistance may have been facilitated by use of fluoroquinolones for treating gonorrhea and other conditions. The prominence of multidrug resistance suggests that using other classes of antimicrobial drugs for purposes other than treating gonorrhea helped increase the prevalence of ciprofloxacin-resistant strains that are also resistant to those drugs.