Giuseppe
Emeritus
[Source: US Centers for Disease Control and Prevention, Emerging Infectious Diseases Journal, full PDF: (LINK). Edited.]
DOI: http://dx.doi.org/10.3201/eid1712.111162
Suggested citation for this article: Marsh GA, Haining J, Hancock TJ, Robinson R, Foord AJ, Barr JA, et al. Experimental infection of horses with Hendra virus/Australia/Horse/2008/ Redlands. Emerg Infect Dis [serial on the Internet]. 2011 Dec [date cited]. http://dx.doi.org/10.3201/eid1712.111162
Experimental infection of horses with Hendra virus/Australia/Horse/2008/ Redlands
Glenn A. Marsh, Jessica Haining, Timothy J. Hancock, Rachel Robinson, Adam J. Foord, Jennifer A. Barr, Shane Riddell, Hans G. Heine, John R. White, Gary Crameri, Hume E. Field, Lin-Fa Wang, and Deborah Middleton
Author affiliations: Commonwealth Scientific and Industrial Research Organization Livestock Industries, Geelong, Victoria, Australia (G.A. Marsh, J. Haining, T.J. Hancock, R. Robinson, A.J. Foord, J.A. Barr, S. Riddell, H.G. Heine, J.R. White, G. Crameri, L.-F. Wang, D. Middleton); and Queensland Centre for Emerging Infectious Disease, Coopers Plains, Queensland, Australia (H.E. Field)
Hendra virus (HeV) is a highly pathogenic zoonotic paramyxovirus harbored by Australian flying foxes with sporadic spillovers directly to horses. Although the mode and critical control points of HeV spillover to horses from flying foxes, and the risk for transmission from infected horses to other horses and humans, are poorly understood, we successfully established systemic HeV disease in 3 horses exposed to Hendra virus/Australia/Horse/2008/Redlands by the oronasal route, a plausible route for natural infection. In 2 of the 3 animals, HeV RNA was detected continually in nasal swabs from as early as 2 days postexposure, indicating that systemic spread of the virus may be preceded by local viral replication in the nasal cavity or nasopharynx. Our data suggest that a critical factor for reducing HeV exposure risk to humans includes early consideration of HeV in the differential diagnosis and institution of appropriate infection control procedures.
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DOI: http://dx.doi.org/10.3201/eid1712.111162
Suggested citation for this article: Marsh GA, Haining J, Hancock TJ, Robinson R, Foord AJ, Barr JA, et al. Experimental infection of horses with Hendra virus/Australia/Horse/2008/ Redlands. Emerg Infect Dis [serial on the Internet]. 2011 Dec [date cited]. http://dx.doi.org/10.3201/eid1712.111162
Experimental infection of horses with Hendra virus/Australia/Horse/2008/ Redlands
Glenn A. Marsh, Jessica Haining, Timothy J. Hancock, Rachel Robinson, Adam J. Foord, Jennifer A. Barr, Shane Riddell, Hans G. Heine, John R. White, Gary Crameri, Hume E. Field, Lin-Fa Wang, and Deborah Middleton
Author affiliations: Commonwealth Scientific and Industrial Research Organization Livestock Industries, Geelong, Victoria, Australia (G.A. Marsh, J. Haining, T.J. Hancock, R. Robinson, A.J. Foord, J.A. Barr, S. Riddell, H.G. Heine, J.R. White, G. Crameri, L.-F. Wang, D. Middleton); and Queensland Centre for Emerging Infectious Disease, Coopers Plains, Queensland, Australia (H.E. Field)
Hendra virus (HeV) is a highly pathogenic zoonotic paramyxovirus harbored by Australian flying foxes with sporadic spillovers directly to horses. Although the mode and critical control points of HeV spillover to horses from flying foxes, and the risk for transmission from infected horses to other horses and humans, are poorly understood, we successfully established systemic HeV disease in 3 horses exposed to Hendra virus/Australia/Horse/2008/Redlands by the oronasal route, a plausible route for natural infection. In 2 of the 3 animals, HeV RNA was detected continually in nasal swabs from as early as 2 days postexposure, indicating that systemic spread of the virus may be preceded by local viral replication in the nasal cavity or nasopharynx. Our data suggest that a critical factor for reducing HeV exposure risk to humans includes early consideration of HeV in the differential diagnosis and institution of appropriate infection control procedures.
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