tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2022 Dec 18;29(1).
doi: 10.3201/eid2901.220996. Online ahead of print.
Effects of Second Dose of SARS-CoV-2 Vaccination on Household Transmission, England
Asad Zaidi, Ross Harris, Jennifer Hall, Sarah Woodhall, Nick Andrews, Kevin Dunbar, Jamie Lopez-Bernal, Gavin Dabrera
Abstract
A single SARS-CoV-2 vaccine dose reduces onward transmission from case-patients. We assessed the potential effects of receiving 2 doses on household transmission for a dataset of all case-patients in England and their household contacts. We used stratified Cox regression models to calculate hazard ratios (HRs) for the outcome of contacts becoming secondary cases, comparing contacts of 2-dose vaccinated and unvaccinated index cases. Adjustment factors included sex and contact, and relative socioeconomic condition based on household location. HRs for the outcome were 0.19 (0.13-0.28) for contacts of cases who had 2-dose BNT162b2 vaccine and 0.54 (0.41-0.69) for contacts of 2-dose Ch4dOx1 case-patients during the Alpha period, compared with contacts of unvaccinated cases. HRs in the Delta period were 0.74 (0.72-0.76) for BNT162b2 and 1.06 (1.04-1.08) for Ch4dOx1. Reduction of onward transmission was lower for index cases who tested positive ≥2 months after their second dose of either vaccine.
Keywords: Andrews N; COVID-19; Dunbar K; England. Emerg Infect Dis. 2023 Jan [date cited]. https://doi.org/10.3201/eid2901.220996; Hall J; Harris R; SARS-CoV-2; Suggested citation for this article: Zaidi A; United Kingdom; Woodhall S; et al. Effects of second dose of SARS-CoV-2 vaccination on household transmission; household; respiratory infections; severe acute respiratory syndrome coronavirus 2; transmission; vaccination; viruses; zoonoses.
. 2022 Dec 18;29(1).
doi: 10.3201/eid2901.220996. Online ahead of print.
Effects of Second Dose of SARS-CoV-2 Vaccination on Household Transmission, England
Asad Zaidi, Ross Harris, Jennifer Hall, Sarah Woodhall, Nick Andrews, Kevin Dunbar, Jamie Lopez-Bernal, Gavin Dabrera
- PMID: 36529456
- DOI: 10.3201/eid2901.220996
Abstract
A single SARS-CoV-2 vaccine dose reduces onward transmission from case-patients. We assessed the potential effects of receiving 2 doses on household transmission for a dataset of all case-patients in England and their household contacts. We used stratified Cox regression models to calculate hazard ratios (HRs) for the outcome of contacts becoming secondary cases, comparing contacts of 2-dose vaccinated and unvaccinated index cases. Adjustment factors included sex and contact, and relative socioeconomic condition based on household location. HRs for the outcome were 0.19 (0.13-0.28) for contacts of cases who had 2-dose BNT162b2 vaccine and 0.54 (0.41-0.69) for contacts of 2-dose Ch4dOx1 case-patients during the Alpha period, compared with contacts of unvaccinated cases. HRs in the Delta period were 0.74 (0.72-0.76) for BNT162b2 and 1.06 (1.04-1.08) for Ch4dOx1. Reduction of onward transmission was lower for index cases who tested positive ≥2 months after their second dose of either vaccine.
Keywords: Andrews N; COVID-19; Dunbar K; England. Emerg Infect Dis. 2023 Jan [date cited]. https://doi.org/10.3201/eid2901.220996; Hall J; Harris R; SARS-CoV-2; Suggested citation for this article: Zaidi A; United Kingdom; Woodhall S; et al. Effects of second dose of SARS-CoV-2 vaccination on household transmission; household; respiratory infections; severe acute respiratory syndrome coronavirus 2; transmission; vaccination; viruses; zoonoses.