tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2021 Sep 1;27(11).
doi: 10.3201/eid2711.211449. Online ahead of print.
Effectiveness of Abbott BinaxNOW Rapid Antigen Test for Detection of SARS-CoV-2 Infections in Outbreak among Horse Racetrack Workers, California, USA
Krishna Surasi, Kristin J Cummings, Carl Hanson, Mary Kate Morris, Maria Salas, David Seftel, Liza Ortiz, Ruwan Thilakaratne, Cameron Stainken, Debra A Wadford
Abstract
The Abbott BinaxNOW rapid antigen test is cheaper and faster than real-time reverse transcription PCR (rRT-PCR) for detecting severe acute respiratory syndrome coronavirus 2. We compared BinaxNOW with rRT-PCR in 769 paired specimens from 342 persons during a coronavirus disease outbreak among horse racetrack workers in California, USA. We found positive percent agreement was 43.3% (95% CI 34.6%-52.4%), negative percent agreement 100% (95% CI 99.4%-100%), positive predictive value 100% (95% CI 93.5%-100%), and negative predictive value 89.9% (95% CI 87.5%-92.0%). Among 127 rRT-PCR-positive specimens, the 55 with paired BinaxNOW-positive results had a lower mean cycle threshold than the 72 with paired BinaxNOW-negative results (17.8 vs. 28.5; p<0.001). Of 100 specimens with cycle threshold <30, a total of 51 resulted in positive virus isolation; 45 (88.2%) of those were BinaxNOW-positive. Our comparison supports immediate isolation for BinaxNOW-positive persons and confirmatory testing for negative persons.
Keywords: COVID-19; SARS-CoV-2; SARS-CoV-2 RT-PCR testing; SARS-CoV-2 antigen testing; coronavirus disease; disease outbreaks; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; workplace; zoonoses.
. 2021 Sep 1;27(11).
doi: 10.3201/eid2711.211449. Online ahead of print.
Effectiveness of Abbott BinaxNOW Rapid Antigen Test for Detection of SARS-CoV-2 Infections in Outbreak among Horse Racetrack Workers, California, USA
Krishna Surasi, Kristin J Cummings, Carl Hanson, Mary Kate Morris, Maria Salas, David Seftel, Liza Ortiz, Ruwan Thilakaratne, Cameron Stainken, Debra A Wadford
- PMID: 34469287
- DOI: 10.3201/eid2711.211449
Abstract
The Abbott BinaxNOW rapid antigen test is cheaper and faster than real-time reverse transcription PCR (rRT-PCR) for detecting severe acute respiratory syndrome coronavirus 2. We compared BinaxNOW with rRT-PCR in 769 paired specimens from 342 persons during a coronavirus disease outbreak among horse racetrack workers in California, USA. We found positive percent agreement was 43.3% (95% CI 34.6%-52.4%), negative percent agreement 100% (95% CI 99.4%-100%), positive predictive value 100% (95% CI 93.5%-100%), and negative predictive value 89.9% (95% CI 87.5%-92.0%). Among 127 rRT-PCR-positive specimens, the 55 with paired BinaxNOW-positive results had a lower mean cycle threshold than the 72 with paired BinaxNOW-negative results (17.8 vs. 28.5; p<0.001). Of 100 specimens with cycle threshold <30, a total of 51 resulted in positive virus isolation; 45 (88.2%) of those were BinaxNOW-positive. Our comparison supports immediate isolation for BinaxNOW-positive persons and confirmatory testing for negative persons.
Keywords: COVID-19; SARS-CoV-2; SARS-CoV-2 RT-PCR testing; SARS-CoV-2 antigen testing; coronavirus disease; disease outbreaks; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; workplace; zoonoses.