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Emerg Infect Dis . Early-Season Detection of Influenza A(H3N2) Subclade K in Wastewater, Colorado, USA, 2025-2026

tetano

Editor, Senior Moderator
Emerg Infect Dis

. 2026 Aug;32(13):66-70.
doi: 10.3201/eid3213.260431.

Early-Season Detection of Influenza A(H3N2) Subclade K in Wastewater, Colorado, USA, 2025-2026​


Molly C Hetherington-Rauth, Van Nguyen, Emily Washeleski, Kevin Castro Vital, Gabrielle Lequia, Deborah Aragon, Nisha B Alden, Kirsten Weisbeck, Laura Bankers, Alexandria Rossheim, Allison Wheeler, Shannon R Matzinger



Free article

Abstract​


We assessed the value of wastewater sequencing for monitoring influenza circulation in Colorado, USA, focusing on the emergence of influenza A(H3N2) subclade K. We detected subclade K in wastewater 31 days before clinical detection. Our results demonstrated that wastewater sequencing can provide real-time situational awareness for public health officials.

Keywords: H3N2; United States; deconvolution; genomics; influenza; influenza A; influenza virus; next-generation sequencing; viruses; wastewater surveillance.
 
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