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Emerg Infect Dis . Dynamics of SARS-CoV-2 Antibody Response to CoronaVac followed by Booster Dose of BNT162b2 Vaccine

tetano

tetano

Editor, Senior Moderator
Emerg Infect Dis


. 2022 Apr 14;28(6).
doi: 10.3201/eid2806.220061. Online ahead of print.
Dynamics of SARS-CoV-2 Antibody Response to CoronaVac followed by Booster Dose of BNT162b2 Vaccine

Marcela Helena Gambim Fonseca, Ana Carolina Matias Dinelly Pinto, Maria Francilene Souza Silva, Amanda Campelo Lima de Melo, Germana Silva Vasconcelos, Eduardo Ruback Dos Santos, Fernanda Montenegro de Carvalho Araújo, Luiz Odorico Monteiro de Andrade

Abstract

We evaluated the longitudinal dynamics of antibody response to the SARS-CoV-2 vaccine CoronaVac and the effect of a booster dose of BNT162b2 vaccine. We found a robust antibody response after the second dose of CoronaVac that wanes over time. The response was recovered by BNT162b2, which boosted anti-spike antibody titers.

Keywords: BNT162b2 vaccine; COVID-19; CoronaVac; SARS-CoV-2; antibody response; coronavirus disease; healthcare workers; respiratory infections; severe acute respiratory syndrome coronavirus 2; vaccine-preventable diseases; viruses; zoonoses.
 
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