tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2021 Jul 27;27(10).
doi: 10.3201/eid2710.211184. Online ahead of print.
Direct and Indirect Effectiveness of mRNA Vaccination against Severe Acute Respiratory Syndrome Coronavirus 2 in Long-Term Care Facilities, Spain
Susana Monge, Carmen Olmedo, Belén Alejos, María Fé Lapeña, María José Sierra, Aurora Limia, COVID-19 Registries Study Group2
Abstract
We conducted a registries-based cohort study of long-term care facility residents >65 years of age offered vaccination against severe acute respiratory syndrome coronavirus 2 before March 10, 2021, in Spain. Risk for infection in vaccinated and nonvaccinated persons was compared with risk in the same persons in a period before the vaccination campaign, adjusted by daily-varying incidence and reproduction number. We selected 299,209 persons; 99.0% had >1 dose, 92.6% had 2 doses, and 99.8% of vaccines were Pfizer/BioNTech (BNT162b2). For vaccinated persons with no previous infection, vaccine effectiveness was 81.8% (95% CI 81.0%-82.7%), and 11.6 (95% CI 11.3-11.9) cases were prevented per 10,000 vaccinated/day. In those with previous infection, effectiveness was 56.8% (95% CI 47.1%-67.7%). In nonvaccinated residents with no previous infection, risk decreased by up to 81.4% (95% CI 73.3%-90.3%). Our results confirm vaccine effectiveness in this population and suggest indirect protection in nonvaccinated persons.
Keywords: COVID-19; SARS-CoV-2; Spain; coronavirus disease; elderly; indirect effects; long-term care facilities; respiratory infections; severe acute respiratory syndrome coronavirus 2; transmissibility; vaccination; vaccine effectiveness; viruses; zoonoses.
. 2021 Jul 27;27(10).
doi: 10.3201/eid2710.211184. Online ahead of print.
Direct and Indirect Effectiveness of mRNA Vaccination against Severe Acute Respiratory Syndrome Coronavirus 2 in Long-Term Care Facilities, Spain
Susana Monge, Carmen Olmedo, Belén Alejos, María Fé Lapeña, María José Sierra, Aurora Limia, COVID-19 Registries Study Group2
- PMID: 34314670
- DOI: 10.3201/eid2710.211184
Abstract
We conducted a registries-based cohort study of long-term care facility residents >65 years of age offered vaccination against severe acute respiratory syndrome coronavirus 2 before March 10, 2021, in Spain. Risk for infection in vaccinated and nonvaccinated persons was compared with risk in the same persons in a period before the vaccination campaign, adjusted by daily-varying incidence and reproduction number. We selected 299,209 persons; 99.0% had >1 dose, 92.6% had 2 doses, and 99.8% of vaccines were Pfizer/BioNTech (BNT162b2). For vaccinated persons with no previous infection, vaccine effectiveness was 81.8% (95% CI 81.0%-82.7%), and 11.6 (95% CI 11.3-11.9) cases were prevented per 10,000 vaccinated/day. In those with previous infection, effectiveness was 56.8% (95% CI 47.1%-67.7%). In nonvaccinated residents with no previous infection, risk decreased by up to 81.4% (95% CI 73.3%-90.3%). Our results confirm vaccine effectiveness in this population and suggest indirect protection in nonvaccinated persons.
Keywords: COVID-19; SARS-CoV-2; Spain; coronavirus disease; elderly; indirect effects; long-term care facilities; respiratory infections; severe acute respiratory syndrome coronavirus 2; transmissibility; vaccination; vaccine effectiveness; viruses; zoonoses.