tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2024 Jan 8;31(2).
doi: 10.3201/eid3102.241147. Online ahead of print.
Comparison of Contemporary and Historic Highly Pathogenic Avian Influenza A(H5N1) Virus Replication in Human Lung Organoids
Meaghan Flagg, Brandi N Williamson, Johan A Ortiz-Morales, Tessa R Lutterman, Emmie de Wit
We compared virus replication and host responses in human alveolar epithelium infected with highly pathogenic avian influenza (HPAI) A(H5N1) viruses. A/Vietnam/1203/2004 replicated most efficiently, followed by A/Texas/37/2024, then A/bovine/Ohio/B24OSU-342/2024. Induction of interferon-stimulated genes was lower with A/Texas/37/2024 and A/bovine/Ohio/B24OSU-342/2024, which may indicate a reduced disease severity of those viruses.
Keywords: H5N1; Influenza A virus; clade 2.3.4.4b; highly pathogenic avian influenza; human lung organoids; influenza; outbreak; respiratory infections; viruses; zoonoses.
. 2024 Jan 8;31(2).
doi: 10.3201/eid3102.241147. Online ahead of print.
Comparison of Contemporary and Historic Highly Pathogenic Avian Influenza A(H5N1) Virus Replication in Human Lung Organoids
Meaghan Flagg, Brandi N Williamson, Johan A Ortiz-Morales, Tessa R Lutterman, Emmie de Wit
- PMID: 39778080
- DOI: 10.3201/eid3102.241147
We compared virus replication and host responses in human alveolar epithelium infected with highly pathogenic avian influenza (HPAI) A(H5N1) viruses. A/Vietnam/1203/2004 replicated most efficiently, followed by A/Texas/37/2024, then A/bovine/Ohio/B24OSU-342/2024. Induction of interferon-stimulated genes was lower with A/Texas/37/2024 and A/bovine/Ohio/B24OSU-342/2024, which may indicate a reduced disease severity of those viruses.
Keywords: H5N1; Influenza A virus; clade 2.3.4.4b; highly pathogenic avian influenza; human lung organoids; influenza; outbreak; respiratory infections; viruses; zoonoses.