Giuseppe
Emeritus
[Source: Emerging Infectious Diseases Journal, full text: (LINK). Extract, edited.]
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Letter
Carbapenem-hydrolyzing Oxacillinase-48 and Oxacillinase-181 in Canada, 2011
To the Editor:
In 2001, a Klebsiella pneumoniae isolate from a patient in Turkey was found to harbor a novel class D carbapenem-hydrolyzing oxacillinase, OXA-48 (1). Although this enzyme hydrolyzes carbapenems at a low level and shows weak activity against expanded-spectrum cephalosporins, it is often associated with other β-lactamases and is multidrug resistant. Reports of Enterobacteriaceae harboring OXA-48 have been described across Europe, the Mediterranean area, and the Middle East (2). In addition, OXA-181, which differs from OXA-48 by 4 aa substitutions, has been described in India (2). We describe the emergence of OXA-48 and OXA-181 in Canada.
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-Carbapenem-hydrolyzing Oxacillinase-48 and Oxacillinase-181 in Canada, 2011
To the Editor:
In 2001, a Klebsiella pneumoniae isolate from a patient in Turkey was found to harbor a novel class D carbapenem-hydrolyzing oxacillinase, OXA-48 (1). Although this enzyme hydrolyzes carbapenems at a low level and shows weak activity against expanded-spectrum cephalosporins, it is often associated with other β-lactamases and is multidrug resistant. Reports of Enterobacteriaceae harboring OXA-48 have been described across Europe, the Mediterranean area, and the Middle East (2). In addition, OXA-181, which differs from OXA-48 by 4 aa substitutions, has been described in India (2). We describe the emergence of OXA-48 and OXA-181 in Canada.
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