tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2026 Oct;32(10):1730-1735.
doi: 10.3201/eid3210.260186.
Seong Cheol Min, Ju Ryeong Lee, Beom Kyu Kim, Ji-Hyun Park, Dong Gyu Lee, Gi Chan Lee, Se Hee An, Santosh Chokkakula, Aman Jain, Young Ki Choi, Yun Hee Baek, Min-Suk Song
Highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b virus continues to cause animal outbreaks and sporadic zoonotic infections. In a mouse model of lethal influenza disease, we compared oseltamivir, baloxavir, and molnupiravir monotherapies with 2-drug combinations. Baloxavir-based combinations improved survival, reduced lung viral loads, and prevented extrapulmonary dissemination, supporting H5N1 preparedness strategies.
Keywords: H5N1 subtype; Influenza; baloxavir; drug combinations; influenza A virus; molnupiravir; oseltamivir; respiratory infections; viruses; zoonoses.
. 2026 Oct;32(10):1730-1735.
doi: 10.3201/eid3210.260186.
Baloxavir-Based Combination Therapy for Protection against Influenza A(H5N1) Clade 2.3.4.4b Virus Infection in Mice
Seong Cheol Min, Ju Ryeong Lee, Beom Kyu Kim, Ji-Hyun Park, Dong Gyu Lee, Gi Chan Lee, Se Hee An, Santosh Chokkakula, Aman Jain, Young Ki Choi, Yun Hee Baek, Min-Suk Song
- PMID: 42811476
- DOI: 10.3201/eid3210.260186
Abstract
Highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b virus continues to cause animal outbreaks and sporadic zoonotic infections. In a mouse model of lethal influenza disease, we compared oseltamivir, baloxavir, and molnupiravir monotherapies with 2-drug combinations. Baloxavir-based combinations improved survival, reduced lung viral loads, and prevented extrapulmonary dissemination, supporting H5N1 preparedness strategies.
Keywords: H5N1 subtype; Influenza; baloxavir; drug combinations; influenza A virus; molnupiravir; oseltamivir; respiratory infections; viruses; zoonoses.