tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2025 Aug;31(8):1640-1644.
doi: 10.3201/eid3108.241844.
ACE2 Receptor Usage across Animal Species by SARS-CoV-2 Variants
Masato Hatta, Gloria P Larson, Yasuko Hatta, Wei Wang, Nannan Jiang, Yu-Jin Jung, Li Wang, Xiaoyu Fan, Brenda M Calderon, Gaston Bonenfant, Xudong Lin, Chenchen Feng, Dan Cui, Ginger Atteberry, Michael Currier, John Steel, David E Wentworth, Bin Zhou
We analyzed the receptor-binding activity and infectivity of 6 representative SARS-CoV-2 lineages in cell lines expressing angiotensin-converting enzyme 2 proteins from 54 different animal species. All viruses demonstrated infectivity in a broad range of species. Susceptible animal species could serve as natural reservoirs or intermediate hosts for SARS-CoV-2.
Keywords: ACE2; COVID-19; One Health; SARS-CoV-2; coronavirus disease; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.
. 2025 Aug;31(8):1640-1644.
doi: 10.3201/eid3108.241844.
ACE2 Receptor Usage across Animal Species by SARS-CoV-2 Variants
Masato Hatta, Gloria P Larson, Yasuko Hatta, Wei Wang, Nannan Jiang, Yu-Jin Jung, Li Wang, Xiaoyu Fan, Brenda M Calderon, Gaston Bonenfant, Xudong Lin, Chenchen Feng, Dan Cui, Ginger Atteberry, Michael Currier, John Steel, David E Wentworth, Bin Zhou
- PMID: 40705397
- DOI: 10.3201/eid3108.241844
We analyzed the receptor-binding activity and infectivity of 6 representative SARS-CoV-2 lineages in cell lines expressing angiotensin-converting enzyme 2 proteins from 54 different animal species. All viruses demonstrated infectivity in a broad range of species. Susceptible animal species could serve as natural reservoirs or intermediate hosts for SARS-CoV-2.
Keywords: ACE2; COVID-19; One Health; SARS-CoV-2; coronavirus disease; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.