tetano
Editor, Senior Moderator
Elife
. 2021 Apr 27;10:e65902.
doi: 10.7554/eLife.65902. Online ahead of print.
Mechanistic theory predicts the effects of temperature and humidity on inactivation of SARS-CoV-2 and other enveloped viruses
Dylan H Morris[SUP] 1 [/SUP], Kwe Claude Yinda[SUP] 2 [/SUP], Amandine Gamble[SUP] 3 [/SUP], Fernando W Rossine[SUP] 1 [/SUP], Qishen Huang[SUP] 4 [/SUP], Trenton Bushmaker[SUP] 5 [/SUP], Robert J Fischer[SUP] 5 [/SUP], M Jeremiah Matson[SUP] 5 [/SUP], Neeltje Van Doremalen[SUP] 6 [/SUP], Peter J Vikesland[SUP] 4 [/SUP], Linsey C Marr[SUP] 4 [/SUP], Vincent J Munster[SUP] 6 [/SUP], James O Lloyd-Smith[SUP] 7 [/SUP]
Affiliations
Abstract
Ambient temperature and humidity strongly affect inactivation rates of enveloped viruses, but a mechanistic, quantitative theory of these effects has been elusive. We measure the stability of SARS-CoV-2 on an inert surface at nine temperature and humidity conditions and develop a mechanistic model to explain and predict how temperature and humidity alter virus inactivation. We find SARS-CoV-2 survives longest at low temperatures and extreme relative humidities (RH); median estimated virus half-life is >24 hours at 10C and 40% RH, but ~1.5 hours at 27C and 65% RH. Our mechanistic model uses fundamental chemistry to explain why inactivation rate increases with increased temperature and shows a U-shaped dependence on RH. The model accurately predicts existing measurements of five different human coronaviruses, suggesting that shared mechanisms may affect stability for many viruses. The results indicate scenarios of high transmission risk, point to mitigation strategies, and advance the mechanistic study of virus transmission.
Keywords: epidemiology; global health; infectious disease; microbiology; viruses.
. 2021 Apr 27;10:e65902.
doi: 10.7554/eLife.65902. Online ahead of print.
Mechanistic theory predicts the effects of temperature and humidity on inactivation of SARS-CoV-2 and other enveloped viruses
Dylan H Morris[SUP] 1 [/SUP], Kwe Claude Yinda[SUP] 2 [/SUP], Amandine Gamble[SUP] 3 [/SUP], Fernando W Rossine[SUP] 1 [/SUP], Qishen Huang[SUP] 4 [/SUP], Trenton Bushmaker[SUP] 5 [/SUP], Robert J Fischer[SUP] 5 [/SUP], M Jeremiah Matson[SUP] 5 [/SUP], Neeltje Van Doremalen[SUP] 6 [/SUP], Peter J Vikesland[SUP] 4 [/SUP], Linsey C Marr[SUP] 4 [/SUP], Vincent J Munster[SUP] 6 [/SUP], James O Lloyd-Smith[SUP] 7 [/SUP]
Affiliations
- PMID: 33904403
- DOI: 10.7554/eLife.65902
Abstract
Ambient temperature and humidity strongly affect inactivation rates of enveloped viruses, but a mechanistic, quantitative theory of these effects has been elusive. We measure the stability of SARS-CoV-2 on an inert surface at nine temperature and humidity conditions and develop a mechanistic model to explain and predict how temperature and humidity alter virus inactivation. We find SARS-CoV-2 survives longest at low temperatures and extreme relative humidities (RH); median estimated virus half-life is >24 hours at 10C and 40% RH, but ~1.5 hours at 27C and 65% RH. Our mechanistic model uses fundamental chemistry to explain why inactivation rate increases with increased temperature and shows a U-shaped dependence on RH. The model accurately predicts existing measurements of five different human coronaviruses, suggesting that shared mechanisms may affect stability for many viruses. The results indicate scenarios of high transmission risk, point to mitigation strategies, and advance the mechanistic study of virus transmission.
Keywords: epidemiology; global health; infectious disease; microbiology; viruses.