tetano
Editor, Senior Moderator
Elife
. 2020 Jul 14;9:e58716.
doi: 10.7554/eLife.58716. Online ahead of print.
Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?
Roger Pique-Regi[SUP] 1 [/SUP], Roberto Romero[SUP] 1 [/SUP], Adi L Tarca[SUP] 2 [/SUP], Francesca Luca[SUP] 1 [/SUP], Yi Xu[SUP] 2 [/SUP], Adnan Alazizi[SUP] 2 [/SUP], Yaozhu Leng[SUP] 2 [/SUP], Chaur-Dong Hsu[SUP] 2 [/SUP], Nardhy Gomez-Lopez[SUP] 2 [/SUP]
Affiliations
Abstract
The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected more than 10 million people, including pregnant women. To date, no consistent evidence for the vertical transmission of SARS-CoV-2 exists. The novel coronavirus canonically utilizes the angiotensin-converting enzyme 2 (ACE2) receptor and the serine protease TMPRSS2 for cell entry. Herein, building upon our previous single-cell study (Pique-Regi, 2019), another study, and new single-cell/nuclei RNA-sequencing data, we investigated the expression of ACE2 and TMPRSS2 throughout pregnancy in the placenta as well as in third-trimester chorioamniotic membranes. We report that co-transcription of ACE2 and TMPRSS2 is negligible in the placenta, thus not a likely path of vertical transmission for SARS-CoV-2. By contrast, receptors for Zika virus and cytomegalovirus, which cause congenital infections, are highly expressed by placental cell types. These data show that the placenta minimally expresses the canonical cell-entry mediators for SARS-CoV-2.
Keywords: genetics; genomics; human; human biology; medicine.
. 2020 Jul 14;9:e58716.
doi: 10.7554/eLife.58716. Online ahead of print.
Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?
Roger Pique-Regi[SUP] 1 [/SUP], Roberto Romero[SUP] 1 [/SUP], Adi L Tarca[SUP] 2 [/SUP], Francesca Luca[SUP] 1 [/SUP], Yi Xu[SUP] 2 [/SUP], Adnan Alazizi[SUP] 2 [/SUP], Yaozhu Leng[SUP] 2 [/SUP], Chaur-Dong Hsu[SUP] 2 [/SUP], Nardhy Gomez-Lopez[SUP] 2 [/SUP]
Affiliations
- PMID: 32662421
- DOI: 10.7554/eLife.58716
Abstract
The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected more than 10 million people, including pregnant women. To date, no consistent evidence for the vertical transmission of SARS-CoV-2 exists. The novel coronavirus canonically utilizes the angiotensin-converting enzyme 2 (ACE2) receptor and the serine protease TMPRSS2 for cell entry. Herein, building upon our previous single-cell study (Pique-Regi, 2019), another study, and new single-cell/nuclei RNA-sequencing data, we investigated the expression of ACE2 and TMPRSS2 throughout pregnancy in the placenta as well as in third-trimester chorioamniotic membranes. We report that co-transcription of ACE2 and TMPRSS2 is negligible in the placenta, thus not a likely path of vertical transmission for SARS-CoV-2. By contrast, receptors for Zika virus and cytomegalovirus, which cause congenital infections, are highly expressed by placental cell types. These data show that the placenta minimally expresses the canonical cell-entry mediators for SARS-CoV-2.
Keywords: genetics; genomics; human; human biology; medicine.