tetano
Editor, Senior Moderator
Clin Vaccine Immunol. 2013 May 22. [Epub ahead of print]
Elevated Inflammatory Mediators in Adults with Oculo-respiratory Syndrome Following Influenza Immunization: A Public Health Agency of Canada/Canadian Institutes of Health Research Influenza Research Network (PCIRN) Study.
Al-Dabbagh M, Lapphra K, Scheifele DW, Halperin SA, Langley JM, Cho P, Kollmann TR, Li Y, De Serres G, Fortuno ES 3rd, Bettinger JA.
Source
College of Medicine, King Saud bin AbdulAziz University for Health Sciences- Jeddah King AbdulAziz Medical City, Jeddah, Saudi Arabia.
Abstract
Introduction: Oculo-respiratory syndrome (ORS) is an infrequent adverse event following influenza vaccination. Clinical presentation suggests ORS is an immune mediated phenomenon but studies of symptomatic individuals are few. This study measured cytokine levels in peripheral blood following influenza vaccination in those with and without current ORS symptoms.Methods: Canadian adults receiving the 2010- 2011 seasonal influenza vaccine were recruited and prompted to rapidly report any adverse effects. ORS symptoms occurring 4-48 hours after vaccination were identified using published criteria. Subjects had two blood samples collected to measure plasma cytokines and hemagglutination inhibition antibody (HAI) titers; Visit one during the acute disease phase or 4-72 hours after vaccination for controls and Visit 2 another 21-days post-immunization.Results: 9 ORS cases and 35 controls were enrolled. ORS cases median age was 49 years, and 89% were females. Most cases had multiple symptoms but none required medical care. HAI titers before and after vaccination were similar for cases and controls. Plasma cytokine concentrations did not differ between ORS cases and controls for most cytokines measured (IL-4, -5, -10, -13, IL-1α, IL-8, TNF-α, IFN-γ, IL-17A). However, ORS cases had higher levels of IL-10, IL-3 when compared to controls at Visit 1 and 2 even when all symptoms had subsided.Conclusion: Persistent higher levels of IL-10 and IL-3 in ORS cases suggest that host factors may have predisposed these individuals to develop ORS following influenza vaccination. Further investigations are warranted, as they could potentially identify subjects at risk prior to vaccination.
PMID:
23697573
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23697573
Elevated Inflammatory Mediators in Adults with Oculo-respiratory Syndrome Following Influenza Immunization: A Public Health Agency of Canada/Canadian Institutes of Health Research Influenza Research Network (PCIRN) Study.
Al-Dabbagh M, Lapphra K, Scheifele DW, Halperin SA, Langley JM, Cho P, Kollmann TR, Li Y, De Serres G, Fortuno ES 3rd, Bettinger JA.
Source
College of Medicine, King Saud bin AbdulAziz University for Health Sciences- Jeddah King AbdulAziz Medical City, Jeddah, Saudi Arabia.
Abstract
Introduction: Oculo-respiratory syndrome (ORS) is an infrequent adverse event following influenza vaccination. Clinical presentation suggests ORS is an immune mediated phenomenon but studies of symptomatic individuals are few. This study measured cytokine levels in peripheral blood following influenza vaccination in those with and without current ORS symptoms.Methods: Canadian adults receiving the 2010- 2011 seasonal influenza vaccine were recruited and prompted to rapidly report any adverse effects. ORS symptoms occurring 4-48 hours after vaccination were identified using published criteria. Subjects had two blood samples collected to measure plasma cytokines and hemagglutination inhibition antibody (HAI) titers; Visit one during the acute disease phase or 4-72 hours after vaccination for controls and Visit 2 another 21-days post-immunization.Results: 9 ORS cases and 35 controls were enrolled. ORS cases median age was 49 years, and 89% were females. Most cases had multiple symptoms but none required medical care. HAI titers before and after vaccination were similar for cases and controls. Plasma cytokine concentrations did not differ between ORS cases and controls for most cytokines measured (IL-4, -5, -10, -13, IL-1α, IL-8, TNF-α, IFN-γ, IL-17A). However, ORS cases had higher levels of IL-10, IL-3 when compared to controls at Visit 1 and 2 even when all symptoms had subsided.Conclusion: Persistent higher levels of IL-10 and IL-3 in ORS cases suggest that host factors may have predisposed these individuals to develop ORS following influenza vaccination. Further investigations are warranted, as they could potentially identify subjects at risk prior to vaccination.
PMID:
23697573
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23697573