tetano
Editor, Senior Moderator
EJHaem
. 2022 May 11;10.1002/jha2.456.
doi: 10.1002/jha2.456. Online ahead of print.
COVID-19-associated secondary hemophagocytic lymphohistiocytosis requiring hematopoietic cell transplant
Jacob R Greenmyer[SUP] 1 [/SUP], Kirk D Wyatt[SUP] 2 [/SUP], Sam Milanovich[SUP] 2 [/SUP], Mira A Kohorst[SUP] 3 [/SUP], Asmaa Ferdjallah[SUP] 3 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) infection causes a variety of extrapulmonary complications in pediatric patients. Multisystem inflammatory syndrome and hemophagocytic lymphohistiocytosis (HLH) are related to hypercytokinemia in COVID-19 patients. HLH is a disorder of exaggerated inflammation resulting in a cytokine storm and unrestricted hemophagocytosis. HLH can be primary (familial) or secondary (acquired). Secondary HLH (sHLH) can occur in patients with rheumatologic, oncologic, or infectious diseases. The link between COVID-19 and HLH has been reported in pediatric patients. Here we report a case of a pediatric patient who developed refractory sHLH secondary to COVID-19 infection and required a hematopoietic cell transplant for the cure.
Keywords: hematology; infection; pediatrics; stem cell transplantation; thrombocytopenia.
. 2022 May 11;10.1002/jha2.456.
doi: 10.1002/jha2.456. Online ahead of print.
COVID-19-associated secondary hemophagocytic lymphohistiocytosis requiring hematopoietic cell transplant
Jacob R Greenmyer[SUP] 1 [/SUP], Kirk D Wyatt[SUP] 2 [/SUP], Sam Milanovich[SUP] 2 [/SUP], Mira A Kohorst[SUP] 3 [/SUP], Asmaa Ferdjallah[SUP] 3 [/SUP]
Affiliations
- PMID: 35941881
- PMCID: PMC9348183
- DOI: 10.1002/jha2.456
Abstract
Coronavirus disease 2019 (COVID-19) infection causes a variety of extrapulmonary complications in pediatric patients. Multisystem inflammatory syndrome and hemophagocytic lymphohistiocytosis (HLH) are related to hypercytokinemia in COVID-19 patients. HLH is a disorder of exaggerated inflammation resulting in a cytokine storm and unrestricted hemophagocytosis. HLH can be primary (familial) or secondary (acquired). Secondary HLH (sHLH) can occur in patients with rheumatologic, oncologic, or infectious diseases. The link between COVID-19 and HLH has been reported in pediatric patients. Here we report a case of a pediatric patient who developed refractory sHLH secondary to COVID-19 infection and required a hematopoietic cell transplant for the cure.
Keywords: hematology; infection; pediatrics; stem cell transplantation; thrombocytopenia.