Giuseppe
Emeritus
DOI: 10.3201/eid1410.060507
Suggested citation for this article: Montgomery JM, Hossain MJ, Gurley E, Carroll DS, Croisier A, Bertherat E, et al. Risk factors for Nipah virus encephalitis in Bangladesh. Emerg Infect Dis. 2008 Oct; [Epub ahead of print]
Risk Factors for Nipah Virus Encephalitis in Bangladesh1
Joel M. Montgomery,2 Mohamed J. Hossain, E. Gurley, D.S. Carroll, A. Croisier, E. Bertherat, N. Asgari, P. Formenty, N. Keeler, J. Comer, M.R. Bell, K. Akram, A.R. Molla, K. Zaman, Mohamed R. Islam, K. Wagoner, J.N. Mills, P.E. Rollin, T.G. Ksiazek, and R.F. Breiman
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (J.M. Montgomery, D.S. Carroll, N. Keeler, J. Comer, M.R. Bell, K. Wagoner, J.N. Mills, P.E. Rollin, T.G. Ksiazek); International Centre for Diarrheal Diseases Research, Dhaka, Bangladesh (M.J. Hossain, E. Gurley, R.F. Breiman); World Health Organization, Geneva, Switzerland (A. Croisier, E. Bertherat, N. Asgari, P. Formenty); World Health Organization, Dhaka (K. Akram, K. Zaman); and Institute of Epidemiology Disease Control and Research; Dhaka (A.R. Molla, M.R. Islam)
1Presented in part at the 54th Annual Meeting of the American Society of Tropical Medicine and Hygiene, 2004 Nov 7?11, Miami, Florida, USA. 2Current affiliation: US Naval Medical Research Center Detachment, Lima, Peru.
Nipah virus (NiV) is a paramyxovirus that causes severe encephalitis in humans.
During January 2004, twelve patients with NiV encephalitis (NiVE) were identified in west-central Bangladesh.
A case?control study was conducted to identify factors associated with NiV infection.
NiVE patients from the outbreak were enrolled in a matched case-control study.
Exact odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using a matched analysis.
Climbing trees (83% of cases vs. 51% of controls, OR 8.2, 95% CI 1.25?∞) and contact with another NiVE patient (67% of cases vs. 9% of controls, OR 21.4, 95% CI 2.78?966.1) were associated with infection.
We did not identify an increased risk for NiV infection among persons who had contact with a potential intermediate host.
Although we cannot rule out person-to-person transmission, case-patients were likely infected from contact with fruit bats or their secretions.
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http://www.cdc.gov/eid/content/14/10/pdfs/06-0507.pdf
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Suggested citation for this article: Montgomery JM, Hossain MJ, Gurley E, Carroll DS, Croisier A, Bertherat E, et al. Risk factors for Nipah virus encephalitis in Bangladesh. Emerg Infect Dis. 2008 Oct; [Epub ahead of print]
Risk Factors for Nipah Virus Encephalitis in Bangladesh1
Joel M. Montgomery,2 Mohamed J. Hossain, E. Gurley, D.S. Carroll, A. Croisier, E. Bertherat, N. Asgari, P. Formenty, N. Keeler, J. Comer, M.R. Bell, K. Akram, A.R. Molla, K. Zaman, Mohamed R. Islam, K. Wagoner, J.N. Mills, P.E. Rollin, T.G. Ksiazek, and R.F. Breiman
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (J.M. Montgomery, D.S. Carroll, N. Keeler, J. Comer, M.R. Bell, K. Wagoner, J.N. Mills, P.E. Rollin, T.G. Ksiazek); International Centre for Diarrheal Diseases Research, Dhaka, Bangladesh (M.J. Hossain, E. Gurley, R.F. Breiman); World Health Organization, Geneva, Switzerland (A. Croisier, E. Bertherat, N. Asgari, P. Formenty); World Health Organization, Dhaka (K. Akram, K. Zaman); and Institute of Epidemiology Disease Control and Research; Dhaka (A.R. Molla, M.R. Islam)
1Presented in part at the 54th Annual Meeting of the American Society of Tropical Medicine and Hygiene, 2004 Nov 7?11, Miami, Florida, USA. 2Current affiliation: US Naval Medical Research Center Detachment, Lima, Peru.
Nipah virus (NiV) is a paramyxovirus that causes severe encephalitis in humans.
During January 2004, twelve patients with NiV encephalitis (NiVE) were identified in west-central Bangladesh.
A case?control study was conducted to identify factors associated with NiV infection.
NiVE patients from the outbreak were enrolled in a matched case-control study.
Exact odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using a matched analysis.
Climbing trees (83% of cases vs. 51% of controls, OR 8.2, 95% CI 1.25?∞) and contact with another NiVE patient (67% of cases vs. 9% of controls, OR 21.4, 95% CI 2.78?966.1) were associated with infection.
We did not identify an increased risk for NiV infection among persons who had contact with a potential intermediate host.
Although we cannot rule out person-to-person transmission, case-patients were likely infected from contact with fruit bats or their secretions.
-
http://www.cdc.gov/eid/content/14/10/pdfs/06-0507.pdf
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