tetano
Editor, Senior Moderator
Avian Influenza A(H7N9) Virus Infection in Pregnant Woman, China, 2013
Article Contents
To the Editor: In February 2013, human infection with reassortant avian influenza A(H7N9) virus occurred in eastern China. A total of 135 laboratory-confirmed cases and 44 deaths among case-patients have been reported as of August 11, 2013. Unlike infection with other H7 subtype viruses (e.g., H7N2, H7N2, and H7N7), which often cause mild-to-moderate-human disease (1), infection with H7N9 subtype virus caused severe pneumonia and acute respiratory distress syndrome in most laboratory-confirmed case-patients (2,3). Pregnant women are particularly susceptible to severe complications from influenza (seasonal and pandemic), and have an increased risk for maternal death (4).
On March 30, 2013, a 25-year-old pregnant woman came to the outpatient department of a hospital in Zhenjiang, Jiangsu Province, China. She had cough and fever (temperature 38.0?C), which had begun 2 days earlier. She also reported mild myalgia and mild sore throat. The patient had no any underlying medical conditions and was at 17 weeks gestation, as estimated by ultrasound. On April 5, she was admitted to the respiratory department of the hospital with a temperature of 39.9?C, a leukocyte count of 7.9 ?109 cells/L, and a lymphocyte count of 0.7 ? 109 cells/L.
On April 6, she was transferred to the intensive care unit because of shortness of breath, respiratory failure, and loss of consciousness. She was given mechanical ventilation, broad-spectrum antimicrobial drugs, oseltamivir, gamma-globulin, antifibrotic therapy (glutathione), and nutritional support. Oseltamivir (150 mg/d, 2 times/d) had been administered during April 6?12. A chest radiograph showed extensive infiltrates of both lungs.
On April 21, she regained consciousness, and her condition stabilized over the next few days. On April 23, she was extubated, transferred to the common ward, and given nasal oxygen supplementation and antimicrobial and antifibrotic drug therapy. Her condition improved gradually, and on May 14 she was discharged in good health without fetal abnormality.
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http://wwwnc.cdc.gov/eid/article/20/2/13-1109_article.htm
Article Contents
To the Editor: In February 2013, human infection with reassortant avian influenza A(H7N9) virus occurred in eastern China. A total of 135 laboratory-confirmed cases and 44 deaths among case-patients have been reported as of August 11, 2013. Unlike infection with other H7 subtype viruses (e.g., H7N2, H7N2, and H7N7), which often cause mild-to-moderate-human disease (1), infection with H7N9 subtype virus caused severe pneumonia and acute respiratory distress syndrome in most laboratory-confirmed case-patients (2,3). Pregnant women are particularly susceptible to severe complications from influenza (seasonal and pandemic), and have an increased risk for maternal death (4).
On March 30, 2013, a 25-year-old pregnant woman came to the outpatient department of a hospital in Zhenjiang, Jiangsu Province, China. She had cough and fever (temperature 38.0?C), which had begun 2 days earlier. She also reported mild myalgia and mild sore throat. The patient had no any underlying medical conditions and was at 17 weeks gestation, as estimated by ultrasound. On April 5, she was admitted to the respiratory department of the hospital with a temperature of 39.9?C, a leukocyte count of 7.9 ?109 cells/L, and a lymphocyte count of 0.7 ? 109 cells/L.
On April 6, she was transferred to the intensive care unit because of shortness of breath, respiratory failure, and loss of consciousness. She was given mechanical ventilation, broad-spectrum antimicrobial drugs, oseltamivir, gamma-globulin, antifibrotic therapy (glutathione), and nutritional support. Oseltamivir (150 mg/d, 2 times/d) had been administered during April 6?12. A chest radiograph showed extensive infiltrates of both lungs.
On April 21, she regained consciousness, and her condition stabilized over the next few days. On April 23, she was extubated, transferred to the common ward, and given nasal oxygen supplementation and antimicrobial and antifibrotic drug therapy. Her condition improved gradually, and on May 14 she was discharged in good health without fetal abnormality.
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http://wwwnc.cdc.gov/eid/article/20/2/13-1109_article.htm