Egyptian girl dies of bird flu / mother also in hospital

[wetDirt]

wild bird links or?

wild bird links or?

Wild Bird Linkage with H5N1 Positive Case in Jakarta
Recombinomics Commentary
February 6, 2007

In Indonesia, which has reported the most avian-flu deaths worldwide, the virus infected a man in his 30s and a 15-year-old girl, who may have gotten the virus from a wild bird, a health ministry official said today.

``She caught a wild bird near her home and it was reported the bird died two days later,'' said Joko Suyono, an official at the ministry's avian-flu information center. The girl was admitted to Jakarta's Persahabatan Hospital yesterday, five days after she developed flu-like symptoms, he said.

The above comments provide a link between a confirmed H5N1 case (15F) in Jakarta with a wild bird. The girl lived in an upscale neighborhood in Jakarta, and the failure to link the case to domestic poultry is similar to the circumstances surrounding first H5N1 cluster in Tangerang, adjacent to Jakarta.

snip...

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This and the Egyptian girl who also claimed infection by wild bird don't sound quite right. In both cases, the consequence of mentioning a poultry source causes all the poultry/kept birds in the area to be slaughtered, and attaches a social stigma. I'd rather just compare sequences, and not pay much attention to what people claim as a source of infection. There are too many reasons people may mistake or misstate the source. Let the data decide.

 

[Theresa42]

Re: Egyptian girl dies of bird flu / mother also in hospital

Egyptian authorities weren't able to detect H5N1 from Nadi's samples? It was NAMRU that confirmed her?

Google-translated from Arabic:

Three stories of the death of the victim No. 12 of avian flu
Feb 7, 2007
Wrote Tariq Amin and meet Bakri Mohamed Farghali

With the formal announcement of the death of the victim No. 12 Banfelonz a bird in the province of Fayoum, It Nora Club <17 years>, There were several accounts of the cause of death.

Dr. Hussein Abutalb Sophie, Undersecretary of the Ministry of Health in Fayyoum, l <Egyptian today>: Different sampling results from the girl suffered the death of confirming <turn of the virus>.

He pointed to inconsistencies Abutalb which happened in the case <Nora> between the results of laboratory tests conducted by the Center Yeh to the Ministry of Health for the disease, and the results of the sample sent to the laboratory of <Alenamro> [NAMRU] group of the American navy, He said that the results of the analysis of the negative health factor, While the results of the analysis <Alenamro> [NAMRU] positive pressed him.

In the official version again, Dr. Amr Qandil, head of the Central Administration did not Fights infection in the Ministry of Health: that <Nora> died four days ago [i.e. Feb 2], two days before the formal announcement of her death as a result deciding H5N1 avian influenza, in accordance with the assurances by the Ministry of Health and World Health Organization e.

The Qandil told <Egyptian today> that Nora underwent treatment in one of the private clinics in Fayoum, pointing out that the doctor as a condition <Tivoed> on Aat Parr did not disclose to the doctor for Mkhalttha birds.

And turn around and the different symptoms of the virus than ever before, Ahmed al-Hadidi, professor of chest diseases at Cairo University, that the symptoms did not differ, He pointed out that the problem is to resist the virus Ela Qar <Altamiflo> [in Nadi??]. He explained that the symptoms are new pneumonia pain Zdoj, and the water on the lung, and brain inflammation, in addition to the eye and throat inflammation and asthma.

http://www.almasry-alyoum.com/article.aspx?ArticleID=47256&r=t

 

[Theresa42]

Re: Egyptian girl dies of bird flu / mother also in hospital

Egyptian authorities weren't able to detect H5N1 from Nadi's samples? It was NAMRU that confirmed her?

Google-translated from Arabic:

Three stories of the death of the victim No. 12 of avian flu
Feb 7, 2007
Wrote Tariq Amin and meet Bakri Mohamed Farghali

With the formal announcement of the death of the victim No. 12 Banfelonz a bird in the province of Fayoum, It Nora Club <17 years>, There were several accounts of the cause of death.

Dr. Hussein Abutalb Sophie, Undersecretary of the Ministry of Health in Fayyoum, l <Egyptian today>: Different sampling results from the girl suffered the death of confirming <turn of the virus>.

He pointed to inconsistencies Abutalb which happened in the case <Nora> between the results of laboratory tests conducted by the Center Yeh to the Ministry of Health for the disease, and the results of the sample sent to the laboratory of <Alenamro> [NAMRU] group of the American navy, He said that the results of the analysis of the negative health factor, While the results of the analysis <Alenamro> [NAMRU] positive pressed him.

In the official version again, Dr. Amr Qandil, head of the Central Administration did not Fights infection in the Ministry of Health: that <Nora> died four days ago [i.e. Feb 2], two days before the formal announcement of her death as a result deciding H5N1 avian influenza, in accordance with the assurances by the Ministry of Health and World Health Organization e.

The Qandil told <Egyptian today> that Nora underwent treatment in one of the private clinics in Fayoum, pointing out that the doctor as a condition <Tivoed> on Aat Parr did not disclose to the doctor for Mkhalttha birds.

And turn around and the different symptoms of the virus than ever before, Ahmed al-Hadidi, professor of chest diseases at Cairo University, that the symptoms did not differ, He pointed out that the problem is to resist the virus Ela Qar <Altamiflo> [in Nadi??]. He explained that the symptoms are new pneumonia pain Zdoj, and the water on the lung, and brain inflammation, in addition to the eye and throat inflammation and asthma.

http://www.almasry-alyoum.com/article.aspx?ArticleID=47256&r=t

Another translation...

Three narrations of the victim's death of a number 12 to the bird flu
Feb 7, 2007

With the declaration officially about the victim's death of a number 12 by the bird flu in Al Fayum Governate, and she "a light a club" [Nouri Nadi] 17 a year, several novels [stories] appeared to the death reasons.

Doctor Hussein Sophie Aboutalb, the Ministry of Health deputy in Al Fayyum, said to "The Egyptian Today": that the difference of the results of the taken samples from the dead girl "a change to the virus" confirms an occurrence.

And Abu Taleb pointed to the conflict that happened in a condition "a light" [Nouri] between the analyses results that the central laboratories held to the Ministry of Health to its disease, and between the sample results sent to the laboratory of "Namro" belonging to the American navy, and it said that the health laboratories analyses results came a passivity [negative], while analyses results confirmed "Namro" the positivity of condition.

And in another official novel [story], doctor Amr Qandil the central department president for Al Adawi's fighting in the Ministry of Health said: "A light" [Nouri] was dead before 4 days, any before two days of the declaration officially about its death due to their injury by the bird flu virus, according to the confirmations of Ministry of Health and World Health Organization.

And Qandil confirmed to "The Egyptian Today" that a light [Nouri] was submitted to the treatment in one of the special clinics in Al Fayyum, explaining that the doctor is its condition person that it is "a typhoid" [i.e. they diagnosed her as having typhoid] considering that it did not reveal to the doctor its mixing the birds.

And around the change of virus and the difference of its symptoms about a before, confirmed doctor Ahmed Al Hadidi the professor of the chest diseases in the Cairo University, the symptoms did not differ, pointing out that the problem became in the resistance of virus to the drug of "Al Tamiflou". And he explained that the new [?] symptoms are the double pneumonia, and waters on the lung, and an inflammation in the brain, to the side of ophthalmia and throat and the dyspnea.

 

[Theresa42]

Re: Egyptian girl dies of bird flu / mother also in hospital

Hat-tip, highflyer!

An update of the confirmed human cases of avian influenza A (H5N1) in Egypt
8 February 2007

Case Number: 20
Age: 17 years
Sex: female
Governorate: Fayoum

Exposure: the woman was exposed to infected and dead backyard birds (Chickens and ducks) several days before onset of symptoms. 150 birds died in that house. Some were slaughtered. Currently there are no birds in the house.

Clinical history: the patient developed the symptoms on 25 January 2007 and was initially treated for seasonal influenza. She was hospitalized in Fayyoum fever hospital on the 1st of February 2007 with fever and difficulty in Breathing.

Laboratory: Two throat swabs and one blood specimen were taken on the 2nd of February 2007 and sent to the Central Public Health Laboratories and NAMRU-3 for testing. The results were positive for H5N1. Genomic characterization of the virus is in process in the laboratories of Centers for Disease Control, CDC, in Atlanta.

Treatment: the patient was treated with Tamiflu and Adamine and interrupted oxygen.

Referral: On February 2, 4:00 pm, the patient was referred to Abbasiya chest hospital in Cairo but because of her critical condition they stopped at the Omraniyya chest hospital where she died.

Of the 20 cases confirmed to date in Egypt, 12 have been fatal.

http://www.emro.who.int/ [<< prolly not a permalink]

 

[HenryN]

Re: Egyptian girl dies of bird flu / mother also in hospital

Hat-tip, highflyer!

An update of the confirmed human cases of avian influenza A (H5N1) in Egypt
8 February 2007

Case Number: 20
Age: 17 years
Sex: female
Governorate: Fayoum

Exposure: the woman was exposed to infected and dead backyard birds (Chickens and ducks) several days before onset of symptoms. 150 birds died in that house. Some were slaughtered. Currently there are no birds in the house.

Clinical history: the patient developed the symptoms on 25 January 2007 and was initially treated for seasonal influenza. She was hospitalized in Fayyoum fever hospital on the 1st of February 2007 with fever and difficulty in Breathing.

Laboratory: Two throat swabs and one blood specimen were taken on the 2nd of February 2007 and sent to the Central Public Health Laboratories and NAMRU-3 for testing. The results were positive for H5N1. Genomic characterization of the virus is in process in the laboratories of Centers for Disease Control, CDC, in Atlanta.

Treatment: the patient was treated with Tamiflu and Adamine and interrupted oxygen.

Referral: On February 2, 4:00 pm, the patient was referred to Abbasiya chest hospital in Cairo but because of her critical condition they stopped at the Omraniyya chest hospital where she died.

Of the 20 cases confirmed to date in Egypt, 12 have been fatal.

http://www.emro.who.int/ [<< prolly not a permalink]

Sequence is similar to Beni Suef, but also has S227N.

 

[Theresa42]

Re: Egyptian girl dies of bird flu / mother also in hospital

Sequence is similar to Beni Suef, but also has S227N.

Beni Suef (aka Bani Suwayf) and Al Fayyum (Fayoum) are neighboring governorates:

Bani Suwayf Governorate:
http://en.wikipedia.org/wiki/Bani_Suwayf_Governorate

Al Fayyum Governorate:
http://en.wikipedia.org/wiki/Al_Fayyum_Governorate

 

[Theresa42]

Re: Egyptian girl dies of bird flu / mother also in hospital

Beni Suef (aka Bani Suwayf) and Al Fayyum (Fayoum) are neighboring governorates:

Bani Suwayf Governorate:
http://en.wikipedia.org/wiki/Bani_Suwayf_Governorate

Al Fayyum Governorate:
http://en.wikipedia.org/wiki/Al_Fayyum_Governorate

Warda Eid Ahmed, the case from Bani Suwayf, was from (I think) near Hillyah in Bani Suwayf governorate [source].

Nouri Nadi, the case from Al Fayyum governorate, was from Al Fayyum city [source].

These are ca. 30 miles away from each other (as the crow flies) -- (map of Hillyah).

 

[HenryN]

Re: Egyptian girl dies of bird flu / mother also in hospital

Commentary at

http://www.recombinomics.com/News/02090703/Egypt_S227N_2007.html

 

[AlaskaDenise]

Re: Egyptian girl dies of bird flu / mother also in hospital

Commentary at

http://www.recombinomics.com/News/02090703/Egypt_S227N_2007.html

Commentary

S227N Re-emerges in Qinghai H5N1 in Egypt
Recombinomics Commentary
February 9, 2007

NAMRU-3 has generated HA and NA sequences from H5N1 from the recent confirmed case in Fayyoum. These sequences are very similar to the HA and NA sequences from A/Egypt/0636-NAMRU3/2007 from the patient in nearby Beni Suef. Like the earlier HA sequence, there is a 3 BP deletion in the recent isolate.

However, the HA sequence was a mixture that included S227N, which is linked to increased affinity for human receptors.

S227N was first reported in both isolates from a family in Hong Kong who had gone to Fujian province for a visit in early 2003. The daughter died in China with bird flu symptoms and H5N1 was isolated from the father and son in Hong Kong. The father died, but both isolates (on MDCK cells from dog kidney) had S227N. A screening of H5N1 isolates in a receptor binding assay identified these two isolates as having increased affinity for 2,6 gal and decreased affinity for 2,3 gal.

Donor sequences for the acquisition of S227N in Qinghai H5N1 were present in H9N2 isolate that were almost exclusively in the Middle East. A warning was issued October 22, 2005 before Qinghai H5N1 had been confirmed in any human. S227N was then found in the index case for Turkey in early 2006. However, it was not in the isolate from his sister. Two additional sequences have been released, and S227N was in one of the two. Thus, S227N was in two of the four HA sequences from patients in Turkey, but in only one of the two siblings.

S227N was also in an human isolate from Egypt last year and S227N was found in an additional patient in Vietnam. However, the published data from a patient in Vietnam showed that S227N was in only one of three clones from that patient (all isolated with MDCK cells), indicating that patients with S227N had mixtures, and detecting S227N was most easily accomplished by looking at multiples clones from the same patient.

The latest sequence also is a mixture at the position encoding S227N. One sequence is wild type (with an A) while the other codes for S227N (with a G).

Although recent papers indicate H5N1 can be found in the upper respiratory tract, even when the binding preference is 2,3, sequences with a 2,6 preference lead to more sneezing (in ferrets described in Science), providing a mechanism for easier transmission. Thus, samples with S227N are more likely to lead to larger human clusters

S227N in Qinghai isolates from two patients in Turkey as well as two patients in Egypt indicates this receptor binding domain change is a major concern for the region.


.

 

[HenryN]

Re: Egyptian girl dies of bird flu / mother also in hospital

An update of the confirmed human cases of avian influenza A (H5N1) in Egypt
8 February 2007

Case Number: 20
Age: 17 years
Sex: female
Governorate: Fayoum
Exposure: the woman was exposed to infected and dead backyard birds (Chickens and ducks) several days before onset of symptoms. 150 birds died in that house. Some were slaughtered. Currently there are no birds in the house.
Clinical history: the patient developed the symptoms on 25 January 2007 and was initially treated for seasonal influenza. She was hospitalized in Fayyoum fever hospital on the 1st of February 2007with fever and difficulty in Breathing.
Laboratory: Two throat swabs and one blood specimen were taken on the 2nd of February 2007 and sent to the Central Public Health Laboratories and NAMRU-3 for testing. The results were positive for H5N1. Genomic characterization of the virus is in process in the laboratories of Centers for Disease Control, CDC, in Atlanta.
Treatment: the patient was treated with Tamiflu and Adamine and interrupted oxygen.
Referral: On February 2, 4:00 pm, the patient was referred to Abbasiya chest hospital in Cairo but because of her critical condition they stopped at the Omraniyya chest hospital where she died.
Of the 20 cases confirmed to date in Egypt, 12 have been fatal.

http://www.emro.who.int/​