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The recent isolates are both recombinants and reasortants. The Aswan sequences have HA from one source (probably Qinghai H5N1 in Aswan) and NA from Beni Suef / Fayyoum. The NA match is quite clear and sequences from Aswan will be required to identify the other parent, but the HA has a Mongolian cleavage site (these are recombinants as well as reassortants).Dr. Niman,
You mention the word "reassortants" in your 3/21 post on your Website. What other strain could they have reassorted with? You mention in the linked post that the strain responsible for the 3 deletions is not Qinghai, so I am wondering if this marks the beginning of yet another clade. Also, since influenza likes to play "King of the Mountain," does this perhaps mean the end of the Tamiflu-resistant polymorphism?
Thanks.
Commentary
Commentary
ChinaAre there other areas with overlapping flyways that show evidence of rapid H5N1 evolution?
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Actually, the rate of evolution is linked to many factors, including the diversity of the H5N1 in the dual infections. China has a great deal of H5N1 genetic diversity as well as dual infections, with some selection pressure applied by mismatched vaccines.Then throw in mutation-driving vaccinations, & it's no wonder we see what we see?
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The above travel log is of a SNP, but it is a SNP with a very specific distribution.How many other changes in NA are there between Indo and Egypt? Is this a SNP or is it a chunk of a dozen?
*wanders off visualizing long-range migratory flying cats... Bar-headed geese adopting kittens and flying them over the Himalayas to Egypt...*
*mrrrooooooowww* *whump*