tetano
Editor, Senior Moderator
Prev Med. 2014 Jan 25. pii: S0091-7435(14)00032-2. doi: 10.1016/j.ypmed.2014.01.015. [Epub ahead of print]
Efficacy of face masks and respirators in preventing upper respiratory tract bacterial colonization and co-infection in hospital healthcare workers.
Macintyre CR1, Wang Q2, Rahman B3, Seale H3, Ridda I1, Gao Z3, Yang P2, Shi W2, Pang X2, Zhang Y2, Moa A4, Dwyer DE5.
Author information
Abstract
OBJECTIVE:
We compared the efficacy of medical masks (MM) and N95 respirators (N95) in preventing bacterial colonization/infection in healthcare workers (HCWs).
METHODS:
A cluster randomised clinical trial (RCT) of 1441 hospital HCWs randomized to medical masks or N95 respirators, and compared to 481 control HCWs, was performed in Beijing, China, during the winter season of 2008-2009. Participants were followed for development of clinical respiratory illness (CRI). Symptomatic subjects were tested for Streptococcus pneumoniae, Bordetella pertussis, Chlamydophilia pneumoniae, Mycoplasma pneumoniae or Haemophilus influenza type B by multiplex polymerase chain reaction (PCR).
RESULTS:
The rate of bacterial colonization was 2.8% in the N95 group (p=0.02), 5.3% among medical mask users (p<0.01) and 7.5% among the controls (p=0.16). N95 respirators were significantly protective (adjusted RR 0.34, 95% CI: 0.21-0.56) against bacterial colonization. Co-infections of two bacteria or a virus and bacteria occurred in up to 3.7% of HCWs, and were significantly lower in the N95 arm.
CONCLUSIONS:
N95 respirators were significantly protective against bacterial colonization, co-colonization and viral-bacterial co-infection. We showed that dual respiratory virus or bacterial-viral co-infections can be reduced by the use of N95 respirators. This study has occupational health and safety implications for health workers.
Copyright ? 2014 The Authors. Published by Elsevier Inc. All rights reserved.
KEYWORDS:
N95 respirators and medical masks, bacterial colonization, healthcare workers, hospitals
PMID:
24472436
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24472436
Efficacy of face masks and respirators in preventing upper respiratory tract bacterial colonization and co-infection in hospital healthcare workers.
Macintyre CR1, Wang Q2, Rahman B3, Seale H3, Ridda I1, Gao Z3, Yang P2, Shi W2, Pang X2, Zhang Y2, Moa A4, Dwyer DE5.
Author information
Abstract
OBJECTIVE:
We compared the efficacy of medical masks (MM) and N95 respirators (N95) in preventing bacterial colonization/infection in healthcare workers (HCWs).
METHODS:
A cluster randomised clinical trial (RCT) of 1441 hospital HCWs randomized to medical masks or N95 respirators, and compared to 481 control HCWs, was performed in Beijing, China, during the winter season of 2008-2009. Participants were followed for development of clinical respiratory illness (CRI). Symptomatic subjects were tested for Streptococcus pneumoniae, Bordetella pertussis, Chlamydophilia pneumoniae, Mycoplasma pneumoniae or Haemophilus influenza type B by multiplex polymerase chain reaction (PCR).
RESULTS:
The rate of bacterial colonization was 2.8% in the N95 group (p=0.02), 5.3% among medical mask users (p<0.01) and 7.5% among the controls (p=0.16). N95 respirators were significantly protective (adjusted RR 0.34, 95% CI: 0.21-0.56) against bacterial colonization. Co-infections of two bacteria or a virus and bacteria occurred in up to 3.7% of HCWs, and were significantly lower in the N95 arm.
CONCLUSIONS:
N95 respirators were significantly protective against bacterial colonization, co-colonization and viral-bacterial co-infection. We showed that dual respiratory virus or bacterial-viral co-infections can be reduced by the use of N95 respirators. This study has occupational health and safety implications for health workers.
Copyright ? 2014 The Authors. Published by Elsevier Inc. All rights reserved.
KEYWORDS:
N95 respirators and medical masks, bacterial colonization, healthcare workers, hospitals
PMID:
24472436
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24472436