Mary Wilson
Well-known member
Published online July 7, 2022.
doi:10.1001/jamaoto.2022.1573
Shruti Gupta, MD[SUP]1,2[/SUP]; Jake J. Lee, MD, MSCI[SUP]1[/SUP]; Amber Perrin, BA[SUP]1[/SUP]; et al
Key Points
Question Is the use of theophylline added to saline nasal irrigation efficacious and safe for treatment of COVID-19–related olfactory dysfunction?
Findings In this phase 2 randomized clinical trial of 51 adults with chronic COVID-19–related olfactory dysfunction, the number of participants who self-reported improvement in their olfactory function after using theophylline nasal irrigation was 16% higher than those receiving placebo (59% vs 43%). The theophylline arm had 24% more participants with a clinically meaningful change in their objective smell identification test score.
Meaning The use of theophylline added to saline nasal irrigations may result in clinically beneficial improvements in smell function compared with saline irrigation alone.
Abstract
Importance Recent studies suggest that theophylline added to saline nasal irrigation (SNI) can be an effective treatment for postviral olfactory dysfunction (OD), a growing public health concern during the COVID-19 pandemic.
Objective To evaluate the efficacy and safety of theophylline added to SNI compared with placebo for COVID-19–related OD. ...
https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2793987
doi:10.1001/jamaoto.2022.1573
Shruti Gupta, MD[SUP]1,2[/SUP]; Jake J. Lee, MD, MSCI[SUP]1[/SUP]; Amber Perrin, BA[SUP]1[/SUP]; et al
Key Points
Question Is the use of theophylline added to saline nasal irrigation efficacious and safe for treatment of COVID-19–related olfactory dysfunction?
Findings In this phase 2 randomized clinical trial of 51 adults with chronic COVID-19–related olfactory dysfunction, the number of participants who self-reported improvement in their olfactory function after using theophylline nasal irrigation was 16% higher than those receiving placebo (59% vs 43%). The theophylline arm had 24% more participants with a clinically meaningful change in their objective smell identification test score.
Meaning The use of theophylline added to saline nasal irrigations may result in clinically beneficial improvements in smell function compared with saline irrigation alone.
Abstract
Importance Recent studies suggest that theophylline added to saline nasal irrigation (SNI) can be an effective treatment for postviral olfactory dysfunction (OD), a growing public health concern during the COVID-19 pandemic.
Objective To evaluate the efficacy and safety of theophylline added to SNI compared with placebo for COVID-19–related OD. ...
https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2793987