tetano
Editor, Senior Moderator
Bioorg Med Chem. 2012 Jun 4. [Epub ahead of print]
Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action.
Fioravanti R, Celestino I, Costi R, Cuzzucoli Crucitti G, Pescatori L, Mattiello L, Novellino E, Checconi P, Palamara AT, Nencioni L, Santo RD.
Source
Istituto Pasteur Cenci Bolognetti - Dip. Chimica e Tecnologie del Farmaco, "Sapienza" University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
Abstract
A set of polyphenol compounds was synthesized and assayed for their ability in inhibiting influenza A virus replication. A sub-set of them showed low toxicity. The best compounds within this sub-set were 4 and 6g, which inhibited the viral replication in a dose-dependent manner. The antiviral activity of these molecules was demonstrated to be caused by their interference with intracellular pathways exploited for viral replication: (1) MAP kinases controlling nuclear-cytoplasmic traffic of viral ribonucleoprotein complex; (2) redox-sensitive pathways, involved in maturation of viral hemagglutinin protein.
Copyright ? 2012 Elsevier Ltd. All rights reserved.
PMID:
22743086
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22743086
Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action.
Fioravanti R, Celestino I, Costi R, Cuzzucoli Crucitti G, Pescatori L, Mattiello L, Novellino E, Checconi P, Palamara AT, Nencioni L, Santo RD.
Source
Istituto Pasteur Cenci Bolognetti - Dip. Chimica e Tecnologie del Farmaco, "Sapienza" University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
Abstract
A set of polyphenol compounds was synthesized and assayed for their ability in inhibiting influenza A virus replication. A sub-set of them showed low toxicity. The best compounds within this sub-set were 4 and 6g, which inhibited the viral replication in a dose-dependent manner. The antiviral activity of these molecules was demonstrated to be caused by their interference with intracellular pathways exploited for viral replication: (1) MAP kinases controlling nuclear-cytoplasmic traffic of viral ribonucleoprotein complex; (2) redox-sensitive pathways, involved in maturation of viral hemagglutinin protein.
Copyright ? 2012 Elsevier Ltd. All rights reserved.
PMID:
22743086
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22743086