Effects of orally administered bovine lactoferrin and lactoperoxidase on influenza virus infection in mice

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Milk contains a wide variety of host protective factors against infectious microbes. Among these protective factors, lactoferrin (LF) and lactoperoxidase (LPO) have been reported to exhibit antiviral activities as well as immuno-modulatory effects. In the present study, the effects of orally administered LF and LPO were assessed in a mouse influenza virus infection model. BALB/c mice were intranasally infected with 6.6 x 102 p.f.u. of influenza virus A/PR/8/34(H1N1). Bovine LF or LPO was administered once daily at a dose of 62.5 mg per mouse by gavage, starting 1 day before infection. Mice given LF or LPO showed a significantly lower lung consolidation score on day 6 after infection compared with the control mice that were given water instead. Concurrently, the number of infiltrated leukocytes recovered from bronchoalveolar lavage fluid (BALF) on day 6 was significantly lower in mice given LF or LPO. However, the virus yield in the BALF was not affected by these treatments. The serum level of IL-6, a pro-inflammatory cytokine, positively correlated with the lung consolidation score in each group and was significantly lower on day 6 in the mice given LPO. These results suggest the potential of oral administration of LF or LPO to attenuate pneumonia in influenza-virus-infected mice through the suppression of infiltration of inflammatory cells in the lung.
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Full study:
http://jmm.sgmjournals.org/cgi/content/full/54/8/717

 

[gsgs]

Re: Effects of orally administered bovine lactoferrin and lactoperoxidase on influenza virus infection in mice

This article has been cited by other articles:

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H. Wakabayashi, N. Takakura, K. Yamauchi, and Y. Tamura
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Clin. Vaccine Immunol., February 1, 2006; 13(2): 239 - 245.




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Re: Effects of orally administered bovine lactoferrin and lactoperoxidase on influenza virus infection in mice

Here is a list of the references included in the study. Your second reference is a very good review, which led me to this study. I'm going to post a link to it.

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[gsgs]

Re: Effects of orally administered bovine lactoferrin and lactoperoxidase on influenza virus infection in mice

no indication that milk-drinkers have fewer flu AFAIK.

China has surprisingly low milk consumption, how did they do in 1918 ?

milk consumption is proportional to genetical predisposition
towards lactose ingestion, (don't remember the exact
condition) I read.

 

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Re: Effects of orally administered bovine lactoferrin and lactoperoxidase on influenza virus infection in mice

Maybe milk drinkers just have milder symptoms?
Depending on the amounts of milk consumed?

I wonder what % of nursing babies get the flu.