tetano
Editor, Senior Moderator
Clinical Infectious Diseases 2010;50:963?969
? 2010 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2010/5007-0003$15.00
DOI: 10.1086/651083
MAJOR ARTICLE
Effects of Early Oseltamivir Therapy on Viral Shedding in 2009 Pandemic Influenza A (H1N1) Virus Infection
Li M. Ling,1
Angela L. Chow,2
David C. Lye,1
Adriana S. Tan,2
Prabha Krishnan,3
Lin Cui,3
Nwe N. Win,2
Monica Chan,1
Poh L. Lim,1
Cheng C. Lee,1 and
Yee S. Leo1
Departments of 1Infectious Diseases, 2Clinical Epidemiology, and 3Laboratory Medicine, Tan Tock Seng Hospital, Singapore
Background.Pandemic influenza (H1N1) 2009 is susceptible to oseltamivir. There are few reports on its clinical and virologic response to oseltamivir.
Methods.During the pandemic containment response in Singapore, all patients with positive polymerase chain reaction (PCR) results for pandemic influenza (H1N1) 2009 were hospitalized, given oseltamivir for 5 days, and discharged when daily PCR results for combined nasal and throat swab samples became negative. Six patients had concurrent positive viral culture and PCR results.
Results.The median age of the first 70 consecutive patients was 26 years (interquartile range, 21?38 years); 60% were men, and 29% had comorbidity. The mean time (?SD) from illness onset to hospital admission was days. Influenza‐like illness was noted in 63% of patients. Fever occurred in 91%, cough in 88%, sore throat in 66%, and rhinorrhea in 53% of patients. The mean duration (?SD) of viral shedding from illness onset was days. Viral shedding persisted beyond 7 days in 37% of patients. Clinical features and viral shedding were similar between those with and without comorbidity, except the former had more cough and lower oxygen saturation. Patients receiving oseltamivir on days 1 to 3 of illness had significantly shorter viral shedding duration, compared with those treated from day 4 onwards ( ). The mean durations (?SD) of positive PCR and viral culture results were and days, respectively, for 6 patients with concurrent positive viral culture and PCR results.
Conclusions.Prolonged viral shedding was noted in young immunocompetent adults with mild pandemic influenza (H1N1) 2009 despite receipt of oseltamivir. When prescribed during the first 3 days of illness, oseltamivir shortened the duration of viral shedding.
http://www.journals.uchicago.edu/do...%7Cany%3A+influenza+h1n1%5D&searchHistoryKey=
? 2010 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2010/5007-0003$15.00
DOI: 10.1086/651083
MAJOR ARTICLE
Effects of Early Oseltamivir Therapy on Viral Shedding in 2009 Pandemic Influenza A (H1N1) Virus Infection
Li M. Ling,1
Angela L. Chow,2
David C. Lye,1
Adriana S. Tan,2
Prabha Krishnan,3
Lin Cui,3
Nwe N. Win,2
Monica Chan,1
Poh L. Lim,1
Cheng C. Lee,1 and
Yee S. Leo1
Departments of 1Infectious Diseases, 2Clinical Epidemiology, and 3Laboratory Medicine, Tan Tock Seng Hospital, Singapore
Background.Pandemic influenza (H1N1) 2009 is susceptible to oseltamivir. There are few reports on its clinical and virologic response to oseltamivir.
Methods.During the pandemic containment response in Singapore, all patients with positive polymerase chain reaction (PCR) results for pandemic influenza (H1N1) 2009 were hospitalized, given oseltamivir for 5 days, and discharged when daily PCR results for combined nasal and throat swab samples became negative. Six patients had concurrent positive viral culture and PCR results.
Results.The median age of the first 70 consecutive patients was 26 years (interquartile range, 21?38 years); 60% were men, and 29% had comorbidity. The mean time (?SD) from illness onset to hospital admission was days. Influenza‐like illness was noted in 63% of patients. Fever occurred in 91%, cough in 88%, sore throat in 66%, and rhinorrhea in 53% of patients. The mean duration (?SD) of viral shedding from illness onset was days. Viral shedding persisted beyond 7 days in 37% of patients. Clinical features and viral shedding were similar between those with and without comorbidity, except the former had more cough and lower oxygen saturation. Patients receiving oseltamivir on days 1 to 3 of illness had significantly shorter viral shedding duration, compared with those treated from day 4 onwards ( ). The mean durations (?SD) of positive PCR and viral culture results were and days, respectively, for 6 patients with concurrent positive viral culture and PCR results.
Conclusions.Prolonged viral shedding was noted in young immunocompetent adults with mild pandemic influenza (H1N1) 2009 despite receipt of oseltamivir. When prescribed during the first 3 days of illness, oseltamivir shortened the duration of viral shedding.
http://www.journals.uchicago.edu/do...%7Cany%3A+influenza+h1n1%5D&searchHistoryKey=
