tetano
Editor, Senior Moderator
Hum Vaccin Immunother. 2013 Jun 3;9(8). [Epub ahead of print]
Effectiveness of seasonal influenza vaccine against clinically diagnosed influenza over two consecutive seasons in children in Guangzhou, China: A matched case-control study.
He Q, Xu J, Chen X, Lu J, Li K, Li Z, Wang M, Yang Q, Dong Z, Liu X, Wu X, Hu W, Zhang D, Lv J, Nie J, Zhu W, Fu C.
Source
Department of Epidemiology; School of Public Health and Tropical Medicine; Southern Medical University; Guangzhou, Guangdong P.R. China; Guangzhou Center for Disease Control and Prevention; Guangzhou, Guangdong P.R. China.
Abstract
Influenza vaccine has to be reformulated each year due to the ever-changing antigenicity of the influenza virus. However, few post-licensure studies of influenza vaccine are available in China. We aimed to measure the effectiveness of seasonal influenza vaccine during two consecutive seasons. Among children in Guangzhou aged 6-59 mo in 2010-2012, we matched each child with clinically diagnosed influenza to three healthy children. Cases with clinically diagnosed influenza were identified from surveillance system. Healthy controls were randomly sampled from the Children's Expanded Programmed Immunization Administrative Computerized System. Conditional logistic regression was used to calculate vaccine effectiveness (VE). A total of 275 matched sets of subjects were included. VE levels against clinically diagnosed influenza for both seasons combined were 55.2% (95%, 21.1, 74.6%) for full vaccination, 45.1% (95% CI, 12.1-65.7%) for any vaccination, respectively. No significant difference was found between VEs for vaccination in both seasons (46.2%) and only in the current season (45.3%). VE by time since vaccination for any vaccination was 33.7% (95% CI, 2.7-54.9%) in 0-5 mo, and no protection was observed in 6-11 mo. Annual, full and timely vaccination should be encouraged for children.
KEYWORDS:
China, case-control studies, children, seasonal influenza, vaccine
PMID:
23733038
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23733038
Effectiveness of seasonal influenza vaccine against clinically diagnosed influenza over two consecutive seasons in children in Guangzhou, China: A matched case-control study.
He Q, Xu J, Chen X, Lu J, Li K, Li Z, Wang M, Yang Q, Dong Z, Liu X, Wu X, Hu W, Zhang D, Lv J, Nie J, Zhu W, Fu C.
Source
Department of Epidemiology; School of Public Health and Tropical Medicine; Southern Medical University; Guangzhou, Guangdong P.R. China; Guangzhou Center for Disease Control and Prevention; Guangzhou, Guangdong P.R. China.
Abstract
Influenza vaccine has to be reformulated each year due to the ever-changing antigenicity of the influenza virus. However, few post-licensure studies of influenza vaccine are available in China. We aimed to measure the effectiveness of seasonal influenza vaccine during two consecutive seasons. Among children in Guangzhou aged 6-59 mo in 2010-2012, we matched each child with clinically diagnosed influenza to three healthy children. Cases with clinically diagnosed influenza were identified from surveillance system. Healthy controls were randomly sampled from the Children's Expanded Programmed Immunization Administrative Computerized System. Conditional logistic regression was used to calculate vaccine effectiveness (VE). A total of 275 matched sets of subjects were included. VE levels against clinically diagnosed influenza for both seasons combined were 55.2% (95%, 21.1, 74.6%) for full vaccination, 45.1% (95% CI, 12.1-65.7%) for any vaccination, respectively. No significant difference was found between VEs for vaccination in both seasons (46.2%) and only in the current season (45.3%). VE by time since vaccination for any vaccination was 33.7% (95% CI, 2.7-54.9%) in 0-5 mo, and no protection was observed in 6-11 mo. Annual, full and timely vaccination should be encouraged for children.
KEYWORDS:
China, case-control studies, children, seasonal influenza, vaccine
PMID:
23733038
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23733038