tetano
Editor, Senior Moderator
Vaccine. 2019 Nov 2. pii: S0264-410X(19)31375-1. doi: 10.1016/j.vaccine.2019.10.012. [Epub ahead of print] [h=1]Effectiveness of repeated influenza vaccination among the elderly population with high annual vaccine uptake rates during the three consecutive A/H3N2 epidemics.[/h]
Song JY[SUP]1[/SUP], Noh JY[SUP]1[/SUP], Lee JS[SUP]2[/SUP], Wie SH[SUP]3[/SUP], Kim YK[SUP]4[/SUP], Lee J[SUP]5[/SUP], Jeong HW[SUP]6[/SUP], Kim SW[SUP]7[/SUP], Lee SH[SUP]8[/SUP], Park KH[SUP]9[/SUP], Choi WS[SUP]10[/SUP], Cheong HJ[SUP]1[/SUP], Kim WJ[SUP]11[/SUP].
[h=3]Author information[/h] 1 Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea; Asian Pacific Influenza Institute (APII), Seoul, South Korea. 2 Division of Infectious Diseases, Department of Internal Medicine, Inha University School of Medicine, Incheon, South Korea. 3 Division of Infectious Diseases, Department of Internal Medicine, Catholic University Medical College, St. Vincent's Hospital, Suwon, South Korea. 4 Division of Infectious Diseases, Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Wonju, South Korea. 5 Division of Infectious Diseases, Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, South Korea. 6 Division of Infectious Diseases, Chungbuk National University College of Medicine, Cheongju, South Korea. 7 Division of Infectious Diseases, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, South Korea. 8 Division of Infectious Diseases, Department of Internal Medicine, Pusan National University School of Medicine, Pusan, South Korea. 9 Division of Infectious Diseases, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, South Korea. 10 Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea. 11 Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea; Asian Pacific Influenza Institute (APII), Seoul, South Korea. Electronic address: wjkim@korea.ac.kr.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Annually, about 80% of the Korean elderly aged ≥65 years receive influenza vaccination. Repeated annual vaccination has been suggested as an important factor of poor influenza vaccine effectiveness (VE), though reported conflicting results.
[h=4]METHODS:[/h] During the consecutive A/H3N2-dominant influenza seasons between 2012 and 2015, we comparatively evaluated the VE (repeated vs. current season only) against laboratory-confirmed influenza, pneumonia and hospitalization in the elderly aged ≥65 years with influenza-like illness (ILI). Clinical and demographic data were collected prospectively, and vaccination status of prior and current seasons was verified using the immunization registry data of Korean Centers for Disease Control and Prevention.
[h=4]RESULTS:[/h] During the first A/H3N2-dominant season in 2012-2013, influenza vaccine showed statistically significant effectiveness against influenza A infection only and when vaccinated in the current season only (VE 53%, 95% CI 15-77). In the latter two seasons (2013-2015 years), the adjusted VE for influenza A was indistinguishable between repeated vaccination and vaccination in the current season only.
[h=4]CONCLUSION:[/h] During consecutive influenza A/H3N2 epidemics, poor influenza vaccine effectiveness may be more pronounced among the elderly population with a high annual vaccine uptake rate.
Copyright ? 2019. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Antigenic determinants; Effectiveness; Hospitalization; Influenza; Pneumonia; Vaccination
PMID: 31690467 DOI: 10.1016/j.vaccine.2019.10.012
Song JY[SUP]1[/SUP], Noh JY[SUP]1[/SUP], Lee JS[SUP]2[/SUP], Wie SH[SUP]3[/SUP], Kim YK[SUP]4[/SUP], Lee J[SUP]5[/SUP], Jeong HW[SUP]6[/SUP], Kim SW[SUP]7[/SUP], Lee SH[SUP]8[/SUP], Park KH[SUP]9[/SUP], Choi WS[SUP]10[/SUP], Cheong HJ[SUP]1[/SUP], Kim WJ[SUP]11[/SUP].
[h=3]Author information[/h] 1 Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea; Asian Pacific Influenza Institute (APII), Seoul, South Korea. 2 Division of Infectious Diseases, Department of Internal Medicine, Inha University School of Medicine, Incheon, South Korea. 3 Division of Infectious Diseases, Department of Internal Medicine, Catholic University Medical College, St. Vincent's Hospital, Suwon, South Korea. 4 Division of Infectious Diseases, Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Wonju, South Korea. 5 Division of Infectious Diseases, Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, South Korea. 6 Division of Infectious Diseases, Chungbuk National University College of Medicine, Cheongju, South Korea. 7 Division of Infectious Diseases, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, South Korea. 8 Division of Infectious Diseases, Department of Internal Medicine, Pusan National University School of Medicine, Pusan, South Korea. 9 Division of Infectious Diseases, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, South Korea. 10 Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea. 11 Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea; Asian Pacific Influenza Institute (APII), Seoul, South Korea. Electronic address: wjkim@korea.ac.kr.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Annually, about 80% of the Korean elderly aged ≥65 years receive influenza vaccination. Repeated annual vaccination has been suggested as an important factor of poor influenza vaccine effectiveness (VE), though reported conflicting results.
[h=4]METHODS:[/h] During the consecutive A/H3N2-dominant influenza seasons between 2012 and 2015, we comparatively evaluated the VE (repeated vs. current season only) against laboratory-confirmed influenza, pneumonia and hospitalization in the elderly aged ≥65 years with influenza-like illness (ILI). Clinical and demographic data were collected prospectively, and vaccination status of prior and current seasons was verified using the immunization registry data of Korean Centers for Disease Control and Prevention.
[h=4]RESULTS:[/h] During the first A/H3N2-dominant season in 2012-2013, influenza vaccine showed statistically significant effectiveness against influenza A infection only and when vaccinated in the current season only (VE 53%, 95% CI 15-77). In the latter two seasons (2013-2015 years), the adjusted VE for influenza A was indistinguishable between repeated vaccination and vaccination in the current season only.
[h=4]CONCLUSION:[/h] During consecutive influenza A/H3N2 epidemics, poor influenza vaccine effectiveness may be more pronounced among the elderly population with a high annual vaccine uptake rate.
Copyright ? 2019. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Antigenic determinants; Effectiveness; Hospitalization; Influenza; Pneumonia; Vaccination
PMID: 31690467 DOI: 10.1016/j.vaccine.2019.10.012