tetano
Editor, Senior Moderator
Pediatr Int. 2013 Sep 11. doi: 10.1111/ped.12221. [Epub ahead of print]
Effectiveness of influenza vaccine in children in day-care centers of Sapporo.
Mori M, Hasegawa J, Showa S, Matsushima A, Ohnishi H, Yoto Y, Tsutsumi H.
Source
Department of Public Health, Sapporo Medical University School of Medicine, South 1, West 17, Chuo-ku, Sapporo, Japan, 060-8556.
Abstract
BACKGROUND:
We conducted a retrospective cohort study for evaluating the effectiveness of the trivalent inactivated influenza vaccine (TIV) among children aged 0 to 6 years in the 2011-2012 season in Sapporo City, Japan, because of scarce evidence.
METHODS:
From 10 day-care centers in Sapporo City, Japan, 629 parents participated in the study. Each parent of the subjects described whether a subject received TIV once or twice in the 2011-2012 season, as well as the exact dates of receiving TIV from record in a maternal and child health handbook marked by a pediatrician. The incidence of influenza was defined as being affected with influenza as diagnosed by a pediatrician. Cox's proportional model was used for calculating a hazard ratio (HR) and its 95% confidence interval (95%CI) of TIV on an influenza incidence.
RESULTS:
After adjusting potential confounding variables such as the day-care center, presence of comorbidity, size of household, number of siblings, and number of smokers in the home in addition to the age and sex of the child, HR was significantly reduced in the subjects aged 1 year (HR=0.22, 95%CI 0.09, 0.54) as well as in the total subjects (HR=0.72, 95%CI 0.52, 0.99). Consequently, the effectiveness of TIV was calculated as 78% for the subjects aged 1 year and 28% for the total subjects.
CONCLUSION:
Our study has suggested that TIV is effective, especially, in the subjects aged 1 year. Further studies are necessary in different seasons, places, and populations to clarify the effectiveness of the influenza vaccine in children.
This article is protected by copyright. All rights reserved.
KEYWORDS:
Children, Effectiveness, Influenza vaccine, Retrospective cohort studies
PMID:
24020935
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24020935
Effectiveness of influenza vaccine in children in day-care centers of Sapporo.
Mori M, Hasegawa J, Showa S, Matsushima A, Ohnishi H, Yoto Y, Tsutsumi H.
Source
Department of Public Health, Sapporo Medical University School of Medicine, South 1, West 17, Chuo-ku, Sapporo, Japan, 060-8556.
Abstract
BACKGROUND:
We conducted a retrospective cohort study for evaluating the effectiveness of the trivalent inactivated influenza vaccine (TIV) among children aged 0 to 6 years in the 2011-2012 season in Sapporo City, Japan, because of scarce evidence.
METHODS:
From 10 day-care centers in Sapporo City, Japan, 629 parents participated in the study. Each parent of the subjects described whether a subject received TIV once or twice in the 2011-2012 season, as well as the exact dates of receiving TIV from record in a maternal and child health handbook marked by a pediatrician. The incidence of influenza was defined as being affected with influenza as diagnosed by a pediatrician. Cox's proportional model was used for calculating a hazard ratio (HR) and its 95% confidence interval (95%CI) of TIV on an influenza incidence.
RESULTS:
After adjusting potential confounding variables such as the day-care center, presence of comorbidity, size of household, number of siblings, and number of smokers in the home in addition to the age and sex of the child, HR was significantly reduced in the subjects aged 1 year (HR=0.22, 95%CI 0.09, 0.54) as well as in the total subjects (HR=0.72, 95%CI 0.52, 0.99). Consequently, the effectiveness of TIV was calculated as 78% for the subjects aged 1 year and 28% for the total subjects.
CONCLUSION:
Our study has suggested that TIV is effective, especially, in the subjects aged 1 year. Further studies are necessary in different seasons, places, and populations to clarify the effectiveness of the influenza vaccine in children.
This article is protected by copyright. All rights reserved.
KEYWORDS:
Children, Effectiveness, Influenza vaccine, Retrospective cohort studies
PMID:
24020935
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24020935