tetano
Editor, Senior Moderator
PLoS One. 2018 Dec 6;13(12):e0207918. doi: 10.1371/journal.pone.0207918. eCollection 2018.
[h=1]Effectiveness of influenza and pneumococcal polysaccharide vaccines against influenza-related outcomes including pneumonia and acute exacerbation of cardiopulmonary diseases: Analysis by dominant viral subtype and vaccine matching.[/h] Song JY[SUP]1,[/SUP][SUP]2[/SUP], Noh JY[SUP]1,[/SUP][SUP]2[/SUP], Lee JS[SUP]3[/SUP], Wie SH[SUP]4[/SUP], Kim YK[SUP]5[/SUP], Lee J[SUP]6[/SUP], Jeong HW[SUP]7[/SUP], Kim SW[SUP]8[/SUP], Lee SH[SUP]9[/SUP], Park KH[SUP]10[/SUP], Choi WS[SUP]1[/SUP], Cheong HJ[SUP]1,[/SUP][SUP]2[/SUP], Kim WJ[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza and pneumonia are leading causes of morbidity and mortality among the elderly. Although vaccination is a main strategy to prevent these infectious diseases, concerns remain with respect to vaccine effectiveness.
[h=4]METHODS:[/h] During three influenza seasons (2014-2015, 2015-2016 and 2016-2017), we evaluated the effectiveness of the influenza and pneumococcal vaccines against pneumonia and acute exacerbation of cardiopulmonary diseases among the elderly aged ≥65 years with influenza-like illness (ILI). Demographic and clinical data were collected prospectively.
[h=4]RESULTS:[/h] Among 2,119 enrolled cases, 1,302 (61.4%) and 871 (41.1%) received the influenza vaccine and 23-valent pneumococcal polysaccharide vaccine (PPV23), respectively. During an A/H3N2-dominant season with poor influenza vaccine effectiveness (2014-2015 season), neither the influenza vaccine nor PPV23 showed significant effectiveness against pneumonia or acute exacerbation of cardiopulmonary diseases. During seasons with good influenza vaccine effectiveness (2015-2016 and 2016-2017 seasons), the influenza vaccine was effective in preventing pneumonia, but PPV23 was not. In particular, the influenza vaccine was effective in preventing acute exacerbation of heart diseases (75.0%) during the A/H1N1-dominant 2015-2016 season.
[h=4]CONCLUSION:[/h] The influenza vaccine was effective in preventing pneumonia only during vaccine-matched seasons with good effectiveness against circulating influenza viruses. In addition, the influenza vaccine was cardio-protective during a vaccine-matched A/H1N1-dominant season.
PMID: 30521553 DOI: 10.1371/journal.pone.0207918
[h=1]Effectiveness of influenza and pneumococcal polysaccharide vaccines against influenza-related outcomes including pneumonia and acute exacerbation of cardiopulmonary diseases: Analysis by dominant viral subtype and vaccine matching.[/h] Song JY[SUP]1,[/SUP][SUP]2[/SUP], Noh JY[SUP]1,[/SUP][SUP]2[/SUP], Lee JS[SUP]3[/SUP], Wie SH[SUP]4[/SUP], Kim YK[SUP]5[/SUP], Lee J[SUP]6[/SUP], Jeong HW[SUP]7[/SUP], Kim SW[SUP]8[/SUP], Lee SH[SUP]9[/SUP], Park KH[SUP]10[/SUP], Choi WS[SUP]1[/SUP], Cheong HJ[SUP]1,[/SUP][SUP]2[/SUP], Kim WJ[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza and pneumonia are leading causes of morbidity and mortality among the elderly. Although vaccination is a main strategy to prevent these infectious diseases, concerns remain with respect to vaccine effectiveness.
[h=4]METHODS:[/h] During three influenza seasons (2014-2015, 2015-2016 and 2016-2017), we evaluated the effectiveness of the influenza and pneumococcal vaccines against pneumonia and acute exacerbation of cardiopulmonary diseases among the elderly aged ≥65 years with influenza-like illness (ILI). Demographic and clinical data were collected prospectively.
[h=4]RESULTS:[/h] Among 2,119 enrolled cases, 1,302 (61.4%) and 871 (41.1%) received the influenza vaccine and 23-valent pneumococcal polysaccharide vaccine (PPV23), respectively. During an A/H3N2-dominant season with poor influenza vaccine effectiveness (2014-2015 season), neither the influenza vaccine nor PPV23 showed significant effectiveness against pneumonia or acute exacerbation of cardiopulmonary diseases. During seasons with good influenza vaccine effectiveness (2015-2016 and 2016-2017 seasons), the influenza vaccine was effective in preventing pneumonia, but PPV23 was not. In particular, the influenza vaccine was effective in preventing acute exacerbation of heart diseases (75.0%) during the A/H1N1-dominant 2015-2016 season.
[h=4]CONCLUSION:[/h] The influenza vaccine was effective in preventing pneumonia only during vaccine-matched seasons with good effectiveness against circulating influenza viruses. In addition, the influenza vaccine was cardio-protective during a vaccine-matched A/H1N1-dominant season.
PMID: 30521553 DOI: 10.1371/journal.pone.0207918