tetano
Editor, Senior Moderator
Vaccine. 2019 Jun 8. pii: S0264-410X(19)30747-9. doi: 10.1016/j.vaccine.2019.05.090. [Epub ahead of print]
[h=1]Effectiveness of inactivated influenza vaccine in children by vaccine dose, 2013-18.[/h] Shinjoh M[SUP]1[/SUP], Sugaya N[SUP]2[/SUP], Furuichi M[SUP]3[/SUP], Araki E[SUP]4[/SUP], Maeda N[SUP]5[/SUP], Isshiki K[SUP]6[/SUP], Ohnishi T[SUP]7[/SUP], Nakamura S[SUP]8[/SUP], Yamada G[SUP]9[/SUP], Narabayashi A[SUP]10[/SUP], Nishida M[SUP]11[/SUP], Taguchi N[SUP]12[/SUP], Nakata Y[SUP]13[/SUP], Yoshida M[SUP]14[/SUP], Tsunematsu K[SUP]15[/SUP], Shibata M[SUP]16[/SUP], Munenaga T[SUP]17[/SUP], Hirano Y[SUP]18[/SUP], Ookawara I[SUP]19[/SUP], Sekiguchi S[SUP]3[/SUP], Kobayashi Y[SUP]20[/SUP], Yamaguchi Y[SUP]21[/SUP], Yoshida N[SUP]22[/SUP], Mitamura K[SUP]23[/SUP], Takahashi T[SUP]3[/SUP]; Keio Pediatric Influenza Research Group.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] We assessed the vaccine effectiveness (VE) of inactivated influenza vaccine (IIV) by vaccine dose in children aged 6 months to 12 years for whom two doses are recommended in Japan to ascertain the appropriate vaccine doses.
[h=4]METHODS:[/h] VE was assessed according to a test-negative case-control design based on rapid influenza diagnostic test (RIDT) results. Children aged 6 months to 12 years with a fever ≥38 ?C who had received an RIDT in outpatient clinics of 24 hospitals were enrolled for all five seasons since 2013/14. VE by vaccine dose (none vs. once or twice, and once vs. twice) was analyzed.
[h=4]RESULTS:[/h] In the dose analysis, 20,033 children were enrolled. Both one- and two-dose regimens significantly reduced cases in preventing any influenza, influenza A, and influenza B, but there was no significant difference in adjusted VE between one- and two-dose regimens overall (adjusted OR, 0.560 [95% CI, 0.505-0.621], 0.550 [95% CI, 0.516-0.586]), 0.549 [95% CI, 0.517-0.583], and 1.014 [95% CI, 0.907-1.135], for none vs. once, none vs. twice, none vs. once or twice, and once vs. twice for any influenza, respectively). Both one- and two-dose regimens significantly reduced cases with any influenza and influenza A every season. Also, both regimens significantly reduced cases of any influenza, influenza A, and influenza B among children aged 1-12 years, especially among those aged 1-5 years. In the 2013/14, 2015/16, and 2016/17 seasons, however, only the two-dose regimen was significantly effective in preventing influenza B. Both one- and two-dose regimens significantly reduced cases involving hospitalization due to any influenza and influenza A.
[h=4]CONCLUSIONS:[/h] Both one- and two-doses regimens of IIV were effective in preventing influenza for children aged 6 months to 12 years. The two-dose regimen was more effective against influenza B in some seasons.
Copyright ? 2019 Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Children; Effectiveness; Hospitalization; Influenza vaccine; Test-negative case control; Vaccine dose
PMID: 31186191 DOI: 10.1016/j.vaccine.2019.05.090
[h=1]Effectiveness of inactivated influenza vaccine in children by vaccine dose, 2013-18.[/h] Shinjoh M[SUP]1[/SUP], Sugaya N[SUP]2[/SUP], Furuichi M[SUP]3[/SUP], Araki E[SUP]4[/SUP], Maeda N[SUP]5[/SUP], Isshiki K[SUP]6[/SUP], Ohnishi T[SUP]7[/SUP], Nakamura S[SUP]8[/SUP], Yamada G[SUP]9[/SUP], Narabayashi A[SUP]10[/SUP], Nishida M[SUP]11[/SUP], Taguchi N[SUP]12[/SUP], Nakata Y[SUP]13[/SUP], Yoshida M[SUP]14[/SUP], Tsunematsu K[SUP]15[/SUP], Shibata M[SUP]16[/SUP], Munenaga T[SUP]17[/SUP], Hirano Y[SUP]18[/SUP], Ookawara I[SUP]19[/SUP], Sekiguchi S[SUP]3[/SUP], Kobayashi Y[SUP]20[/SUP], Yamaguchi Y[SUP]21[/SUP], Yoshida N[SUP]22[/SUP], Mitamura K[SUP]23[/SUP], Takahashi T[SUP]3[/SUP]; Keio Pediatric Influenza Research Group.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] We assessed the vaccine effectiveness (VE) of inactivated influenza vaccine (IIV) by vaccine dose in children aged 6 months to 12 years for whom two doses are recommended in Japan to ascertain the appropriate vaccine doses.
[h=4]METHODS:[/h] VE was assessed according to a test-negative case-control design based on rapid influenza diagnostic test (RIDT) results. Children aged 6 months to 12 years with a fever ≥38 ?C who had received an RIDT in outpatient clinics of 24 hospitals were enrolled for all five seasons since 2013/14. VE by vaccine dose (none vs. once or twice, and once vs. twice) was analyzed.
[h=4]RESULTS:[/h] In the dose analysis, 20,033 children were enrolled. Both one- and two-dose regimens significantly reduced cases in preventing any influenza, influenza A, and influenza B, but there was no significant difference in adjusted VE between one- and two-dose regimens overall (adjusted OR, 0.560 [95% CI, 0.505-0.621], 0.550 [95% CI, 0.516-0.586]), 0.549 [95% CI, 0.517-0.583], and 1.014 [95% CI, 0.907-1.135], for none vs. once, none vs. twice, none vs. once or twice, and once vs. twice for any influenza, respectively). Both one- and two-dose regimens significantly reduced cases with any influenza and influenza A every season. Also, both regimens significantly reduced cases of any influenza, influenza A, and influenza B among children aged 1-12 years, especially among those aged 1-5 years. In the 2013/14, 2015/16, and 2016/17 seasons, however, only the two-dose regimen was significantly effective in preventing influenza B. Both one- and two-dose regimens significantly reduced cases involving hospitalization due to any influenza and influenza A.
[h=4]CONCLUSIONS:[/h] Both one- and two-doses regimens of IIV were effective in preventing influenza for children aged 6 months to 12 years. The two-dose regimen was more effective against influenza B in some seasons.
Copyright ? 2019 Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Children; Effectiveness; Hospitalization; Influenza vaccine; Test-negative case control; Vaccine dose
PMID: 31186191 DOI: 10.1016/j.vaccine.2019.05.090