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Vaccine
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doi:10.1016/j.vaccine.2011.07.087 | How to Cite or Link Using DOI
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Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: A test-negative case control study
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Allen C. Chenga, b, Corresponding Author Contact Information, E-mail The Corresponding Author, Tom Kotsimbosa, b, Heath A. Kellyc, Louis B. Irvingd, e, Simon D. Bowlerf, Simon G.A. Browng, h, i, Mark Holmesj, k, Christine R. Jenkinsl, m, n, Philip Thompsoni, Graham Simpsono, Richard Wood-Bakerp, q, Sanjaya N. Senanayaker, s, Stephen J. Bradyt, David L. Patersonu, v, Peter A. Warkw, x, John W. Uphamu, y, Tony M. Kormana, z, Dominic E. Dwyerl, A, Grant W. Watererg, h and Paul M. Kellys, B
A Westmead Hospital, Australia
B ACT Government Health Directorate, Australia
a Monash University, Australia
b Alfred Hospital, Australia
c Victorian Infectious Diseases Reference Laboratory, Australia
d Royal Melbourne Hospital, Australia
e University of Melbourne, Australia
f Mater Adult Hospital, Australia
g Royal Perth Hospital, Australia
h Western Australian Institute for Medical Research, Australia
i University of Western Australia, Australia
j The University of Adelaide, Australia
k Royal Adelaide Hospital, Australia
l University of Sydney, Australia
m Concord Hospital, Australia
n Woolcock Institute of Medical Research, Australia
o Cairns Base Hospital, Australia
p Royal Hobart Hospital, Australia
q Menzies Research Institute, Australia
r Canberra Hospital, Australia
s Australian National University, Australia
t Alice Springs Hospital, Australia
u University of Queensland, Australia
v Royal Brisbane and Women's Hospital, Australia
w University of Newcastle, Australia
x John Hunter Hospital, Australia
y Princess Alexandra Hospital, Australia
z Southern Health, Australia
Received 28 March 2011;
revised 4 July 2011;
accepted 19 July 2011.
Available online 31 July 2011.
Abstract
We aimed to estimate the effectiveness of H1N1/09 containing influenza vaccines against hospitalization from influenza in Australia. We performed a test-negative case control study in patients hospitalized in 15 sentinel Australian hospitals between March and November 2010, comparing influenza vaccination (H1N1/09 monovalent or 2010 seasonal trivalent) in hospitalized patients with PCR-confirmed influenza compared to PCR-negative controls. Between March and November 2010, 1169 hospitalized patients were tested for suspected influenza, of which influenza vaccine status was ascertained in 165/238 patients with H1N1/09 influenza, 40/64 with seasonal influenza and 558/867 test negative controls; 24% of H1N1/09 cases, 43% of seasonal influenza cases and 54% of controls were vaccinated. VE against hospitalisation with H1N1/09 influenza after adjusting for age, medical comorbidities and pregnancy status was estimated at 49% (95% CI: 13%, 70%). Influenza vaccination was associated with a reduction in hospitalisation caused by H1N1/09 influenza in the 2010 southern hemisphere winter season.
http://www.sciencedirect.com/science/article/pii/S0264410X11011376
Article in Press, Uncorrected Proof - Note to users
doi:10.1016/j.vaccine.2011.07.087 | How to Cite or Link Using DOI
Permissions & Reprints
Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: A test-negative case control study
Purchase
$ 31.50
Allen C. Chenga, b, Corresponding Author Contact Information, E-mail The Corresponding Author, Tom Kotsimbosa, b, Heath A. Kellyc, Louis B. Irvingd, e, Simon D. Bowlerf, Simon G.A. Browng, h, i, Mark Holmesj, k, Christine R. Jenkinsl, m, n, Philip Thompsoni, Graham Simpsono, Richard Wood-Bakerp, q, Sanjaya N. Senanayaker, s, Stephen J. Bradyt, David L. Patersonu, v, Peter A. Warkw, x, John W. Uphamu, y, Tony M. Kormana, z, Dominic E. Dwyerl, A, Grant W. Watererg, h and Paul M. Kellys, B
A Westmead Hospital, Australia
B ACT Government Health Directorate, Australia
a Monash University, Australia
b Alfred Hospital, Australia
c Victorian Infectious Diseases Reference Laboratory, Australia
d Royal Melbourne Hospital, Australia
e University of Melbourne, Australia
f Mater Adult Hospital, Australia
g Royal Perth Hospital, Australia
h Western Australian Institute for Medical Research, Australia
i University of Western Australia, Australia
j The University of Adelaide, Australia
k Royal Adelaide Hospital, Australia
l University of Sydney, Australia
m Concord Hospital, Australia
n Woolcock Institute of Medical Research, Australia
o Cairns Base Hospital, Australia
p Royal Hobart Hospital, Australia
q Menzies Research Institute, Australia
r Canberra Hospital, Australia
s Australian National University, Australia
t Alice Springs Hospital, Australia
u University of Queensland, Australia
v Royal Brisbane and Women's Hospital, Australia
w University of Newcastle, Australia
x John Hunter Hospital, Australia
y Princess Alexandra Hospital, Australia
z Southern Health, Australia
Received 28 March 2011;
revised 4 July 2011;
accepted 19 July 2011.
Available online 31 July 2011.
Abstract
We aimed to estimate the effectiveness of H1N1/09 containing influenza vaccines against hospitalization from influenza in Australia. We performed a test-negative case control study in patients hospitalized in 15 sentinel Australian hospitals between March and November 2010, comparing influenza vaccination (H1N1/09 monovalent or 2010 seasonal trivalent) in hospitalized patients with PCR-confirmed influenza compared to PCR-negative controls. Between March and November 2010, 1169 hospitalized patients were tested for suspected influenza, of which influenza vaccine status was ascertained in 165/238 patients with H1N1/09 influenza, 40/64 with seasonal influenza and 558/867 test negative controls; 24% of H1N1/09 cases, 43% of seasonal influenza cases and 54% of controls were vaccinated. VE against hospitalisation with H1N1/09 influenza after adjusting for age, medical comorbidities and pregnancy status was estimated at 49% (95% CI: 13%, 70%). Influenza vaccination was associated with a reduction in hospitalisation caused by H1N1/09 influenza in the 2010 southern hemisphere winter season.
http://www.sciencedirect.com/science/article/pii/S0264410X11011376