Mary Wilson
Well-known member
July 7, 2021
DOI: 10.1056/NEJMoa2107715
Alejandro Jara, Ph.D., Eduardo A. Undurraga, Ph.D., Cecilia González, M.D., Fabio Paredes, M.Sc., Tomás Fontecilla, M.Sc., Gonzalo Jara, B.S.E., Alejandra Pizarro, M.D., Johanna Acevedo, M.S., Katherine Leo, B.S.E., Francisco Leon, M.B.A., Carlos Sans, B.S.E., Paulina Leighton, B.S.E., et al.
Abstract
BACKGROUND
Mass vaccination campaigns to prevent coronavirus disease 2019 (Covid-19) are occurring in many countries; estimates of vaccine effectiveness are urgently needed to support decision making. A countrywide mass vaccination campaign with the use of an inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine (CoronaVac) was conducted in Chile starting on February 2, 2021.
METHODS
We used a prospective national cohort, including participants 16 years of age or older who were affiliated with the public national health care system, to assess the effectiveness of the inactivated SARS-CoV-2 vaccine with regard to preventing Covid-19 and related hospitalization, admission to the intensive care unit (ICU), and death. We estimated hazard ratios using the extension of the Cox proportional-hazards model, accounting for time-varying vaccination status. We estimated the change in the hazard ratio associated with partial immunization (≥14 days after receipt of the first dose and before receipt of the second dose) and full immunization (≥14 days after receipt of the second dose). Vaccine effectiveness was estimated with adjustment for individual demographic and clinical characteristics.
RESULTS
The study was conducted from February 2 through May 1, 2021, and the cohort included approximately 10.2 million persons. ...
https://www.nejm.org/doi/full/10.1056/NEJMoa2107715?query=featured_home
DOI: 10.1056/NEJMoa2107715
Alejandro Jara, Ph.D., Eduardo A. Undurraga, Ph.D., Cecilia González, M.D., Fabio Paredes, M.Sc., Tomás Fontecilla, M.Sc., Gonzalo Jara, B.S.E., Alejandra Pizarro, M.D., Johanna Acevedo, M.S., Katherine Leo, B.S.E., Francisco Leon, M.B.A., Carlos Sans, B.S.E., Paulina Leighton, B.S.E., et al.
Abstract
BACKGROUND
Mass vaccination campaigns to prevent coronavirus disease 2019 (Covid-19) are occurring in many countries; estimates of vaccine effectiveness are urgently needed to support decision making. A countrywide mass vaccination campaign with the use of an inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine (CoronaVac) was conducted in Chile starting on February 2, 2021.
METHODS
We used a prospective national cohort, including participants 16 years of age or older who were affiliated with the public national health care system, to assess the effectiveness of the inactivated SARS-CoV-2 vaccine with regard to preventing Covid-19 and related hospitalization, admission to the intensive care unit (ICU), and death. We estimated hazard ratios using the extension of the Cox proportional-hazards model, accounting for time-varying vaccination status. We estimated the change in the hazard ratio associated with partial immunization (≥14 days after receipt of the first dose and before receipt of the second dose) and full immunization (≥14 days after receipt of the second dose). Vaccine effectiveness was estimated with adjustment for individual demographic and clinical characteristics.
RESULTS
The study was conducted from February 2 through May 1, 2021, and the cohort included approximately 10.2 million persons. ...
https://www.nejm.org/doi/full/10.1056/NEJMoa2107715?query=featured_home