Effective Induction of High-Titer Antibodies by Viral Vector Vaccines

[sharon sanders]

Brief Communication abstract

<hr class="separator"> Nature Medicine 14, 819 - 821 (2008)
Published online: 27 July 2008 | <abbr title="Digital Object Identifier">doi</abbr>:10.1038/nm.1850
Effective induction of high-titer antibodies by viral vector vaccines

Simon J Draper¹, Anne C Moore^1,⁵, Anna L Goodman¹, Carole A Long², Anthony A Holder³, Sarah C Gilbert¹, Fergal Hill⁴ & Adrian V S Hill¹
Top of pageProtein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus?poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro.

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1. The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, UK.
2. Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, 12735 Twinbrook Parkway, Rockville, Maryland 20852, USA.
3. Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK.
4. Imaxio, 181-203 Avenue Jean Jaur?s, 69007 Lyon, France.
5. Current address: School of Pharmacy, Cavanagh Pharmacy Building, University College Cork, Cork, Ireland.

Correspondence to: Simon J Draper¹ e-mail: simon.draper@ndm.ox.ac.uk


http://www.nature.com/nm/journal/v14/n8/abs/nm.1850.html