tetano
Editor, Senior Moderator
Influenza Other Respir Viruses. 2018 Oct 16. doi: 10.1111/irv.12615. [Epub ahead of print]
[h=1]Effect of Vitamin D supplementation to reduce respiratory infections in children and adolescents in Vietnam: a randomized controlled trial.[/h] Loeb M[SUP]1[/SUP], Dang AD[SUP]2[/SUP], Thiem VD[SUP]3[/SUP], Thanabalan V[SUP]4[/SUP], Wang B[SUP]4[/SUP], Nguyen NB[SUP]5[/SUP], Tran HTM[SUP]2[/SUP], Luong TM[SUP]2[/SUP], Singh P[SUP]4[/SUP], Smieja M[SUP]4[/SUP], Maguire J[SUP]6[/SUP], Pullenayegum E[SUP]7[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] It is uncertain whether Vitamin D can reduce respiratory infection.
[h=4]OBJECTIVE:[/h] To determine if vitamin D supplementation reduces influenza and other upper viral respiratory tract infections.
[h=4]METHODS:[/h] 1,300 healthy children and adolescents between the ages of 3 and 17 years were randomized to vitamin D (14,000U weekly) or placebo for eight months in Vietnam. The primary outcome was reverse transcriptase (RT) -PCR confirmed influenza infection and the co-primary outcome was multiplex PCR confirmed non-influenza respiratory viruses. Participants, care givers, and those assessing outcomes were blinded to group assignment.
[h=4]RESULTS:[/h] 650 children and adolescents were randomly assigned to vitamin D and 650 to placebo. The mean baseline serum 25-hydroxyvitamin D levels were 65.7 nmol/L and 65.2 nmol/L in the intervention and placebo groups respectively, with an increase to 91.8 nmol/L in the vitamin D group and no increase, 64.5 nmol/L, in the placebo group. All 1,300 participants randomized contributed to the analysis. We observed RT-PCR confirmed influenza A or B occurred in 50 children (7.7%) in the vitamin D group and in 43 (6.6%) in the placebo group (hazard ratio
1.18, 95%CI 0.79 to 1.78). RT-PCR confirmed non-influenza respiratory virus infection occurred in 146 (22.5%) in the vitamin D group and in 185 (28.5%) in the placebo group (hazard ratio
0.76, 95% CI 0.61 to 0.94). When considering all respiratory viruses, including influenza, the effect of vitamin D in reducing infection was significant, HR 0.81, 95% CI 0.66 to 0.99.
[h=4]CONCLUSION:[/h] Vitamin D supplementation did not reduce the incidence of influenza but moderately reduced non-influenza respiratory viral infection. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza; randomized trial; respiratory viruses; vitamin D
PMID: 30328294 DOI: 10.1111/irv.12615
Free full text
[h=1]Effect of Vitamin D supplementation to reduce respiratory infections in children and adolescents in Vietnam: a randomized controlled trial.[/h] Loeb M[SUP]1[/SUP], Dang AD[SUP]2[/SUP], Thiem VD[SUP]3[/SUP], Thanabalan V[SUP]4[/SUP], Wang B[SUP]4[/SUP], Nguyen NB[SUP]5[/SUP], Tran HTM[SUP]2[/SUP], Luong TM[SUP]2[/SUP], Singh P[SUP]4[/SUP], Smieja M[SUP]4[/SUP], Maguire J[SUP]6[/SUP], Pullenayegum E[SUP]7[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] It is uncertain whether Vitamin D can reduce respiratory infection.
[h=4]OBJECTIVE:[/h] To determine if vitamin D supplementation reduces influenza and other upper viral respiratory tract infections.
[h=4]METHODS:[/h] 1,300 healthy children and adolescents between the ages of 3 and 17 years were randomized to vitamin D (14,000U weekly) or placebo for eight months in Vietnam. The primary outcome was reverse transcriptase (RT) -PCR confirmed influenza infection and the co-primary outcome was multiplex PCR confirmed non-influenza respiratory viruses. Participants, care givers, and those assessing outcomes were blinded to group assignment.
[h=4]RESULTS:[/h] 650 children and adolescents were randomly assigned to vitamin D and 650 to placebo. The mean baseline serum 25-hydroxyvitamin D levels were 65.7 nmol/L and 65.2 nmol/L in the intervention and placebo groups respectively, with an increase to 91.8 nmol/L in the vitamin D group and no increase, 64.5 nmol/L, in the placebo group. All 1,300 participants randomized contributed to the analysis. We observed RT-PCR confirmed influenza A or B occurred in 50 children (7.7%) in the vitamin D group and in 43 (6.6%) in the placebo group (hazard ratio
1.18, 95%CI 0.79 to 1.78). RT-PCR confirmed non-influenza respiratory virus infection occurred in 146 (22.5%) in the vitamin D group and in 185 (28.5%) in the placebo group (hazard ratio
0.76, 95% CI 0.61 to 0.94). When considering all respiratory viruses, including influenza, the effect of vitamin D in reducing infection was significant, HR 0.81, 95% CI 0.66 to 0.99.
[h=4]CONCLUSION:[/h] Vitamin D supplementation did not reduce the incidence of influenza but moderately reduced non-influenza respiratory viral infection. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza; randomized trial; respiratory viruses; vitamin D
PMID: 30328294 DOI: 10.1111/irv.12615
Free full text