tetano
Editor, Senior Moderator
J Hosp Infect. 2017 Apr 21. pii: S0195-6701(17)30196-2. doi: 10.1016/j.jhin.2017.04.010. [Epub ahead of print]
[h=1]Effect of Target Enriched Multiplex-Polymerase Chain Reaction on patient outcomes and costs during the 2013-14 influenza season.[/h] Hassoun A[SUP]1[/SUP], Huff MD[SUP]2[/SUP], Asis E[SUP]3[/SUP], Chahal K[SUP]3[/SUP], Azarbal A[SUP]3[/SUP], Lu S[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The US Centers for Disease Control and Prevention recommends the initial use of rapid antigen influenza diagnostic test (RIDT) for the detection of influenza A (H1N1-09). Nasopharyngeal samples were tested from 246 patients for H1N1-09 using target-enriched multiplex polymerase chain reaction (TEM-PCR), of which 163 were additionally tested via RIDT. RIDTs had a sensitivity of 18.7% compared with TEM-PCR as the reference standard. Patients with false-negative RIDTs were withheld from 111 days of oseltamivir and 65 days of isolation. Patients negative for H1N1 via TEM-PCR had antiviral therapy immediately stopped, thereby evading 408 days of oseltamivir and 315 days of unnecessary isolation. This cost avoidance saved US$208,982.
Copyright ? 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Antimicrobial stewardship; H1N1; Hospitalization cost reduction; Influenza; Multiplex PCR; Oseltamivir
PMID: 28571763 DOI: 10.1016/j.jhin.2017.04.010
[h=1]Effect of Target Enriched Multiplex-Polymerase Chain Reaction on patient outcomes and costs during the 2013-14 influenza season.[/h] Hassoun A[SUP]1[/SUP], Huff MD[SUP]2[/SUP], Asis E[SUP]3[/SUP], Chahal K[SUP]3[/SUP], Azarbal A[SUP]3[/SUP], Lu S[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The US Centers for Disease Control and Prevention recommends the initial use of rapid antigen influenza diagnostic test (RIDT) for the detection of influenza A (H1N1-09). Nasopharyngeal samples were tested from 246 patients for H1N1-09 using target-enriched multiplex polymerase chain reaction (TEM-PCR), of which 163 were additionally tested via RIDT. RIDTs had a sensitivity of 18.7% compared with TEM-PCR as the reference standard. Patients with false-negative RIDTs were withheld from 111 days of oseltamivir and 65 days of isolation. Patients negative for H1N1 via TEM-PCR had antiviral therapy immediately stopped, thereby evading 408 days of oseltamivir and 315 days of unnecessary isolation. This cost avoidance saved US$208,982.
Copyright ? 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Antimicrobial stewardship; H1N1; Hospitalization cost reduction; Influenza; Multiplex PCR; Oseltamivir
PMID: 28571763 DOI: 10.1016/j.jhin.2017.04.010