tetano
Editor, Senior Moderator
PLoS One. 2016 Dec 15;11(12):e0167281. doi: 10.1371/journal.pone.0167281. eCollection 2016.
[h=1]Effect of Influenza Vaccination of Children on Infection Rate in Hutterite Communities: Follow-Up Study of a Randomized Trial.[/h] Wang B[SUP]1[/SUP], Russell ML[SUP]2[/SUP], Moss L[SUP]1[/SUP], Fonseca K[SUP]3[/SUP], Earn DJ[SUP]4,[/SUP][SUP]5,[/SUP][SUP]6[/SUP], Aoki F[SUP]7[/SUP], Horsman G[SUP]8[/SUP], Caeseele PV[SUP]9[/SUP], Chokani K[SUP]10[/SUP], Vooght M[SUP]11[/SUP], Babiuk L[SUP]12[/SUP], Webby R[SUP]13[/SUP], Walter SD[SUP]3[/SUP], Loeb M[SUP]1,[/SUP][SUP]4,[/SUP][SUP]5,[/SUP][SUP]14[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] An earlier cluster randomized controlled trial (RCT) of Hutterite colonies had shown that if more than 80% of children and adolescents were immunized with influenza vaccine there was a statistically significant reduction in laboratory-confirmed influenza among all unimmunized community members. We assessed the impact of this intervention for two additional influenza seasonal periods.
[h=4]METHODS:[/h] Follow-up data for two influenza seasonal periods of a cluster randomized trial involving 1053 Canadian children and adolescents aged 36 months to 15 years in Season 2 and 1014 in Season 3 who received the study vaccine, and 2805 community members in Season 2 and 2840 in Season 3 who did not receive the study vaccine. Follow-up for Season 2 began November 18, 2009 and ended April 25, 2010 while Season 3 extended from December 6, 2010 and ended May 27, 2011. Children were randomly assigned in a blinded manner according to community membership to receive either inactivated trivalent influenza vaccine or hepatitis A. The primary outcome was confirmed influenza A and B infection using RT-PCR assay. Due to the outbreak of 2009 H1N1 pandemic, data in Season 2 were excluded for analysis.
[h=4]RESULTS:[/h] For an analysis of the combined Season 1 and Season 3 data, among non-recipients (i.e., participants who did not receive study vaccines), 66 of the 2794 (2.4%) participants in the influenza vaccine colonies and 121 of the 2301 (5.3%) participants in the hepatitis A colonies had influenza confirmed by RT-PCR, for a protective effectiveness of 60% (95% CI, 6% to 83%; P = 0.04); among all study participants (i.e., including both those who received study vaccine and those who did not), 125 of the 3806 (3.3%) in the influenza vaccine colonies and 239 of the 3243 (7.4%) in the hepatitis A colonies had influenza confirmed by RT-PCR, for a protective effectiveness of 63% (95% CI, 5% to 85%; P = 0.04).
[h=4]CONCLUSION:[/h] Immunizing children and adolescents with inactivated influenza vaccine can offer a protective effect among unimmunized community members for influenza A and B together when considered over multiple years of seasonal influenza.
[h=4]TRIAL REGISTRATION:[/h] Clinicaltrials.gov NCT00877396.
PMID: 27977707 DOI: 10.1371/journal.pone.0167281
[PubMed - in process] Free full text
[h=1]Effect of Influenza Vaccination of Children on Infection Rate in Hutterite Communities: Follow-Up Study of a Randomized Trial.[/h] Wang B[SUP]1[/SUP], Russell ML[SUP]2[/SUP], Moss L[SUP]1[/SUP], Fonseca K[SUP]3[/SUP], Earn DJ[SUP]4,[/SUP][SUP]5,[/SUP][SUP]6[/SUP], Aoki F[SUP]7[/SUP], Horsman G[SUP]8[/SUP], Caeseele PV[SUP]9[/SUP], Chokani K[SUP]10[/SUP], Vooght M[SUP]11[/SUP], Babiuk L[SUP]12[/SUP], Webby R[SUP]13[/SUP], Walter SD[SUP]3[/SUP], Loeb M[SUP]1,[/SUP][SUP]4,[/SUP][SUP]5,[/SUP][SUP]14[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] An earlier cluster randomized controlled trial (RCT) of Hutterite colonies had shown that if more than 80% of children and adolescents were immunized with influenza vaccine there was a statistically significant reduction in laboratory-confirmed influenza among all unimmunized community members. We assessed the impact of this intervention for two additional influenza seasonal periods.
[h=4]METHODS:[/h] Follow-up data for two influenza seasonal periods of a cluster randomized trial involving 1053 Canadian children and adolescents aged 36 months to 15 years in Season 2 and 1014 in Season 3 who received the study vaccine, and 2805 community members in Season 2 and 2840 in Season 3 who did not receive the study vaccine. Follow-up for Season 2 began November 18, 2009 and ended April 25, 2010 while Season 3 extended from December 6, 2010 and ended May 27, 2011. Children were randomly assigned in a blinded manner according to community membership to receive either inactivated trivalent influenza vaccine or hepatitis A. The primary outcome was confirmed influenza A and B infection using RT-PCR assay. Due to the outbreak of 2009 H1N1 pandemic, data in Season 2 were excluded for analysis.
[h=4]RESULTS:[/h] For an analysis of the combined Season 1 and Season 3 data, among non-recipients (i.e., participants who did not receive study vaccines), 66 of the 2794 (2.4%) participants in the influenza vaccine colonies and 121 of the 2301 (5.3%) participants in the hepatitis A colonies had influenza confirmed by RT-PCR, for a protective effectiveness of 60% (95% CI, 6% to 83%; P = 0.04); among all study participants (i.e., including both those who received study vaccine and those who did not), 125 of the 3806 (3.3%) in the influenza vaccine colonies and 239 of the 3243 (7.4%) in the hepatitis A colonies had influenza confirmed by RT-PCR, for a protective effectiveness of 63% (95% CI, 5% to 85%; P = 0.04).
[h=4]CONCLUSION:[/h] Immunizing children and adolescents with inactivated influenza vaccine can offer a protective effect among unimmunized community members for influenza A and B together when considered over multiple years of seasonal influenza.
[h=4]TRIAL REGISTRATION:[/h] Clinicaltrials.gov NCT00877396.
PMID: 27977707 DOI: 10.1371/journal.pone.0167281
[PubMed - in process] Free full text