tetano
Editor, Senior Moderator
Antiviral Res. 2020 Mar 29:104785. doi: 10.1016/j.antiviral.2020.104785. [Epub ahead of print]
Effect of antiviral treatment in older patients hospitalized with confirmed influenza.
Soldevila N[SUP]1[/SUP], Toledo D[SUP]2[/SUP], Ortiz de Lejarazu R[SUP]3[/SUP], Tamames S[SUP]4[/SUP], Castilla J[SUP]5[/SUP], Astray J[SUP]6[/SUP], Fern?ndez MA[SUP]7[/SUP], Mart?n V[SUP]8[/SUP], Egurrola M[SUP]9[/SUP], Morales Su?rez-Varela M[SUP]10[/SUP], Dom?nguez ?[SUP]11[/SUP]; Working Group of Project PI12/02079.
Collaborators (57)
Author information
Abstract
Seasonal influenza causes significant morbidity and mortality in people aged ≥65 years. Antiviral treatment can reduce complications and disease severity. The objective of this study was to investigate the effect of antiviral treatment in patients aged ≥65 years hospitalized with confirmed influenza in preventing intensive care unit (ICU) admission or death. A cross-sectional study was carried out in 20 hospitals from seven Spanish regions during 2013-2015 in patients aged ≥65 years. Hospitalized cases of laboratory-confirmed influenza were selected. To assess the association between antiviral treatment and ICU admission or death, the adjusted odds ratios (aOR) and their 95% confidence intervals (CI) were calculated using multivariate logistic regression. We included 715 hospitalized patients, of whom 640 (87.9%) received antiviral treatment, 77 (10.8%) required ICU admission and 66 (9.2%) died. In the 64-74 years age group, receipt of antiviral treatment ≤48 h (aOR 0.20; 95% CI 0.04-0.89), 3-4 days (aOR 0.23; 95% CI 0.05-0.92) and 5-7 days (aOR 0.24; 95% CI 0.03-0.91) after clinical symptom onset was associated with reduced mortality. Receipt of treatment >7 days after symptom onset was not associated with reduced mortality. No association of antiviral treatment with reduced mortality was observed in the >74 years age group or with the prevention of ICU admission in any age group. Antiviral treatment had a protective effect in avoiding death in patients aged 65-74 years hospitalized due to influenza when administered ≤48 h after symptom onset and when no more than 7 days had elapsed.
Copyright ? 2020. Published by Elsevier B.V.
KEYWORDS:
Adherence; Antiviral treatment; Hospitalized patients; Influenza; Older people
PMID:32234540DOI:10.1016/j.antiviral.2020.104785
Effect of antiviral treatment in older patients hospitalized with confirmed influenza.
Soldevila N[SUP]1[/SUP], Toledo D[SUP]2[/SUP], Ortiz de Lejarazu R[SUP]3[/SUP], Tamames S[SUP]4[/SUP], Castilla J[SUP]5[/SUP], Astray J[SUP]6[/SUP], Fern?ndez MA[SUP]7[/SUP], Mart?n V[SUP]8[/SUP], Egurrola M[SUP]9[/SUP], Morales Su?rez-Varela M[SUP]10[/SUP], Dom?nguez ?[SUP]11[/SUP]; Working Group of Project PI12/02079.
Collaborators (57)
Author information
Abstract
Seasonal influenza causes significant morbidity and mortality in people aged ≥65 years. Antiviral treatment can reduce complications and disease severity. The objective of this study was to investigate the effect of antiviral treatment in patients aged ≥65 years hospitalized with confirmed influenza in preventing intensive care unit (ICU) admission or death. A cross-sectional study was carried out in 20 hospitals from seven Spanish regions during 2013-2015 in patients aged ≥65 years. Hospitalized cases of laboratory-confirmed influenza were selected. To assess the association between antiviral treatment and ICU admission or death, the adjusted odds ratios (aOR) and their 95% confidence intervals (CI) were calculated using multivariate logistic regression. We included 715 hospitalized patients, of whom 640 (87.9%) received antiviral treatment, 77 (10.8%) required ICU admission and 66 (9.2%) died. In the 64-74 years age group, receipt of antiviral treatment ≤48 h (aOR 0.20; 95% CI 0.04-0.89), 3-4 days (aOR 0.23; 95% CI 0.05-0.92) and 5-7 days (aOR 0.24; 95% CI 0.03-0.91) after clinical symptom onset was associated with reduced mortality. Receipt of treatment >7 days after symptom onset was not associated with reduced mortality. No association of antiviral treatment with reduced mortality was observed in the >74 years age group or with the prevention of ICU admission in any age group. Antiviral treatment had a protective effect in avoiding death in patients aged 65-74 years hospitalized due to influenza when administered ≤48 h after symptom onset and when no more than 7 days had elapsed.
Copyright ? 2020. Published by Elsevier B.V.
KEYWORDS:
Adherence; Antiviral treatment; Hospitalized patients; Influenza; Older people
PMID:32234540DOI:10.1016/j.antiviral.2020.104785