sharon sanders
Editor-in-Chief & President
Immunopathology of highly virulent pathogens: insights from Ebola virus.
Nat Immunol. 2007 Nov;8(11):1159-1164.
<!--AuthorList-->Zampieri CA, Sullivan NJ, Nabel GJ.
[1] Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 4502, Building 40, MSC-3005, 40 Convent Drive, Bethesda, Maryland 20892-3005, USA. [2] Present address: Department of Cancer Biology, Abramson Family Cancer Research Institute, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6142, USA.
Ebola virus is a highly virulent pathogen capable of inducing a frequently lethal hemorrhagic fever syndrome. Accumulating evidence indicates that the virus actively subverts both innate and adaptive immune responses and triggers harmful inflammatory responses as it inflicts direct tissue damage.
The host immune system is ultimately overwhelmed by a combination of inflammatory factors and virus-induced cell damage, particularly in the liver and vasculature, often leading to death from septic shock. We summarize the mechanisms of immune dysregulation and virus-mediated cell damage in Ebola virus-infected patients. Future approaches to prevention and treatment of infection will be guided by answers to unresolved questions about interspecies transmission, molecular mechanisms of pathogenesis, and protective adaptive and innate immune responses to Ebola virus.
http://www.nature.com/ni/journal/v8/n11/abs/ni1519.html;jsessionid=9BFE4E7A364A1C786A2FDCF513BE4C70
Nat Immunol. 2007 Nov;8(11):1159-1164.
<!--AuthorList-->Zampieri CA, Sullivan NJ, Nabel GJ.
[1] Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 4502, Building 40, MSC-3005, 40 Convent Drive, Bethesda, Maryland 20892-3005, USA. [2] Present address: Department of Cancer Biology, Abramson Family Cancer Research Institute, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6142, USA.
Ebola virus is a highly virulent pathogen capable of inducing a frequently lethal hemorrhagic fever syndrome. Accumulating evidence indicates that the virus actively subverts both innate and adaptive immune responses and triggers harmful inflammatory responses as it inflicts direct tissue damage.
The host immune system is ultimately overwhelmed by a combination of inflammatory factors and virus-induced cell damage, particularly in the liver and vasculature, often leading to death from septic shock. We summarize the mechanisms of immune dysregulation and virus-mediated cell damage in Ebola virus-infected patients. Future approaches to prevention and treatment of infection will be guided by answers to unresolved questions about interspecies transmission, molecular mechanisms of pathogenesis, and protective adaptive and innate immune responses to Ebola virus.
http://www.nature.com/ni/journal/v8/n11/abs/ni1519.html;jsessionid=9BFE4E7A364A1C786A2FDCF513BE4C70