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The latest outbreaks of emerging, dangerous pathogens, such as Ebola, MERS-CoV or Zika, emphasise the importance of the rapid development of effective vaccines. However, being able to predict the efficacy of new vaccines is and remains a challenge in vaccine development. DZIF scientists at the Heinrich Pette Institute and the University Medical Centre Hamburg-Eppendorf (UKE) were successful in their study in assessing early on the longer-term immune response in humans after being vaccinated with the newly developed Ebola vaccine "rVSV-ZEBOV." The study results provide approaches for searching for new strategies to improve the efficacy of vaccines.